Research ArticleImmunology

T cell receptor stimulation impairs IL-7 receptor signaling by inducing expression of the microRNA miR-17 to target Janus kinase 1

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Science Signaling  26 Aug 2014:
Vol. 7, Issue 340, pp. ra83
DOI: 10.1126/scisignal.2005221

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Cutting Out a Kinase for T cell Survival

Although the survival of T cells requires signaling by both the T cell receptor (TCR) and the interleukin-7 receptor (IL-7R), stimulation of the TCR intermittently inhibits IL-7R signaling, because constant IL-7R signaling causes T cells to die. The kinase Jak1 (Janus kinase 1) is required for IL-7R signaling, and Katz et al. found that Jak1 was unstable and low in abundance in T cells. Furthermore, activation of the TCR induced the expression of a microRNA that prevented the synthesis of new Jak1 protein, thereby interfering with the ability of IL-7R to signal.

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