Research ArticleImmunology T cell receptor stimulation impairs IL-7 receptor signaling by inducing expression of the microRNA miR-17 to target Janus kinase 1 Gil Katz*,†, Leonid A. Pobezinsky†, Susanna Jeurling, Miho Shinzawa, Francois Van Laethem, and Alfred Singer‡Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.↵‡Corresponding author. E-mail: singera{at}mail.nih.gov ↵* Present address: Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. ↵† These authors contributed equally to this work. See allHide authors and affiliations Science Signaling 26 Aug 2014:Vol. 7, Issue 340, pp. ra83DOI: 10.1126/scisignal.2005221 Gil Katz Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Leonid A. Pobezinsky Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Susanna Jeurling Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Miho Shinzawa Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Francois Van Laethem Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Alfred Singer Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: singera@mail.nih.gov Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 7 no. 340 ra83 DOI: https://doi.org/10.1126/scisignal.2005221 PubMed: 25161318 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received February 25, 2014Accepted August 8, 2014 . Copyright & Usage: Copyright © 2014, American Association for the Advancement of Science Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: August 2014 to February 2021 AbstractFullPdf Aug 2014140894119 Sep 20141280102118 Oct 20141862929 Nov 20141001713 Dec 20141202024 Jan 2015981610 Feb 2015611112 Mar 201518510263 Apr 2015432715 May 201554197 Jun 2015461113 Jul 20155199 Aug 20151229 Sep 201514315 Oct 2015657 Nov 2015444 Dec 20151526 Jan 201630210 Feb 201637212 Mar 20163945 Apr 20162559 May 20163551 Jun 20166246 Jul 20163885 Aug 201660510 Sep 20164286 Oct 201677216 Nov 201653214 Dec 20166345 Jan 20174922 Feb 20175659 Mar 20175465 Apr 20174227 May 20174426 Jun 20173430 Jul 20173032 Aug 20176335 Sep 20173034 Oct 20171733 Nov 20174567 Dec 20173120 Jan 20183865 Feb 20184951 Mar 20184833 Apr 20184656 May 20182611 Jun 20183864 Jul 20182145 Aug 20182282 Sep 201826105 Oct 20183280 Nov 201833115 Dec 201829155 Jan 201946155 Feb 20192565 Mar 20191942 Apr 20191640 May 20191323 Jun 20191971 Jul 20191742 Aug 20191861 Sep 20192221 Oct 20191951 Nov 20192351 Dec 20191843 Jan 20202254 Feb 2020964 Mar 20201962 Apr 20201140 May 20201121 Jun 20201132 Jul 20201220 Aug 2020663 Sep 2020820 Oct 20201970 Nov 20202242 Dec 20201650 Jan 20211483 Feb 2021530 View Full Text
T cell receptor stimulation impairs IL-7 receptor signaling by inducing expression of the microRNA miR-17 to target Janus kinase 1 By Gil Katz, Leonid A. Pobezinsky, Susanna Jeurling, Miho Shinzawa, Francois Van Laethem, Alfred Singer Science Signaling26 Aug 2014 : ra83 Induction of a microRNA that targets a critical kinase enables the T cell receptor to inhibit cytokine receptor signaling. Supplementary Materials
T cell receptor stimulation impairs IL-7 receptor signaling by inducing expression of the microRNA miR-17 to target Janus kinase 1 By Gil Katz, Leonid A. Pobezinsky, Susanna Jeurling, Miho Shinzawa, Francois Van Laethem, Alfred Singer Science Signaling26 Aug 2014 : ra83 Induction of a microRNA that targets a critical kinase enables the T cell receptor to inhibit cytokine receptor signaling. Supplementary Materials