Contents

Contents

• Research Articles

  • Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis

    By Silvia Svegliati, Giusi Marrone, Antonio Pezone, Tatiana Spadoni, Antonella Grieco, Gianluca Moroncini, Domenico Grieco, Maria Vinciguerra, Savina Agnese, Astrid Jüngel, Oliver Distler, Anna Maria Musti, Armando Gabrielli, Enrico V. Avvedimento

    Science Signaling02 Sep 2014 : ra84 Full AccessRestricted Access

    DNA damage not only promotes a mitotic checkpoint response but also activates a pathway that can produce fibrotic disease.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Phosphorylation of the TATA-binding protein activates the spliced leader silencing pathway in Trypanosoma brucei

    By Ronen Hope, Efrat Ben-Mayor, Nehemya Friedman, Konstantin Voloshin, Dipul Biswas, Devorah Matas, Yaron Drori, Arthur Günzl, Shulamit Michaeli

    Science Signaling02 Sep 2014 : ra85 Full AccessRestricted Access

    Kinase signaling links endoplasmic reticulum stress to mRNA trans-splicing in Trypanosoma brucei.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Perspective

  • Closing the Ring: A Fourth Extracellular Loop in Chemokine Receptors

    By Martyna Szpakowska, Danielle Perez Bercoff, Andy Chevigné

    Science Signaling02 Sep 2014 : pe21 Full AccessRestricted Access

    Formation of an additional extracellular loop affects the ligand-binding properties and rigidity of G protein–coupled receptors.

    • Abstract
    • Full Text
    • PDF

• Review

  • New tricks for an old fox: Impact of TGFβ on the DNA damage response and genomic stability

    By Mary Helen Barcellos-Hoff, Francis A. Cucinotta

    Science Signaling02 Sep 2014 : re5 Full AccessRestricted Access

    Inhibiting transforming growth factor–β may improve the toxicity of DNA-damaging agents to tumors.

    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 2 September 2014

    By Shulamit Michaeli, Annalisa M. VanHook

    Science Signaling02 Sep 2014 : pc25 Full AccessRestricted Access

    The kinase PK3 inhibits new protein production in Trypanosoma brucei in response to endoplasmic reticulum stress.

    • Abstract
    • Full Text

• Editors' Choice

  • No Fear, Notch Is Here

    By Leslie K. Ferrarelli

    Science Signaling02 Sep 2014 : ec235 Full AccessRestricted Access

    Activating Notch signaling may prevent the memory of fear.

    • Abstract

  • Tubing with VIP

    By Nancy R. Gough

    Science Signaling02 Sep 2014 : ec236 Full AccessRestricted Access

    The neuropeptide VIP is released by parasympathetic nerves and promotes the development of the salivary gland in mice.

    • Abstract

  • TRIMs for Autophagy

    By Annalisa M. VanHook

    Science Signaling02 Sep 2014 : ec237 Full AccessRestricted Access

    TRIM5α stimulates bulk autophagy and acts as a cargo receptor for selective autophagy.

    • Abstract

  • DOG1 Controls Seed Germination

    By Jason D. Berndt

    Science Signaling02 Sep 2014 : ec238 Full AccessRestricted Access

    DOG1 controls temperature-dependent seed dormancy through effects on gibberellic acid metabolism.

    • Abstract

  • Activating a Receptor to Excite a Neuron

    By Valda K. Vinson

    Science Signaling02 Sep 2014 : ec239 Full AccessRestricted Access

    X-ray structures provide insight into how an ion channel involved in activation of neurons is gated.

    • Abstract

  • T and B Cells’ Intricate Molecular Dance

    By Kristen L. Mueller

    Science Signaling02 Sep 2014 : ec240 Full AccessRestricted Access

    Live-cell imaging in mice reveals the molecular details of B cell selection in germinal centers.

    • Abstract

  • Push Me, Pull You, That’s the Way to Move

    By Stella M. Hurtley

    Science Signaling02 Sep 2014 : ec241 Full AccessRestricted Access

    Human fibroblast migration in a physiological extracellular matrix relies on a polarized intracellular pressure gradient.

    • Abstract