Contents
Vol 7, Issue 341
Contents
Research Articles
- Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis
DNA damage not only promotes a mitotic checkpoint response but also activates a pathway that can produce fibrotic disease.
- Phosphorylation of the TATA-binding protein activates the spliced leader silencing pathway in Trypanosoma brucei
Kinase signaling links endoplasmic reticulum stress to mRNA trans-splicing in Trypanosoma brucei.
Perspective
- Closing the Ring: A Fourth Extracellular Loop in Chemokine Receptors
Formation of an additional extracellular loop affects the ligand-binding properties and rigidity of G protein–coupled receptors.
Review
- New tricks for an old fox: Impact of TGFβ on the DNA damage response and genomic stability
Inhibiting transforming growth factor–β may improve the toxicity of DNA-damaging agents to tumors.
Podcast
- Science Signaling Podcast: 2 September 2014
The kinase PK3 inhibits new protein production in Trypanosoma brucei in response to endoplasmic reticulum stress.
Editors' Choice
- Tubing with VIP
The neuropeptide VIP is released by parasympathetic nerves and promotes the development of the salivary gland in mice.
- TRIMs for Autophagy
TRIM5α stimulates bulk autophagy and acts as a cargo receptor for selective autophagy.
- DOG1 Controls Seed Germination
DOG1 controls temperature-dependent seed dormancy through effects on gibberellic acid metabolism.
- Activating a Receptor to Excite a Neuron
X-ray structures provide insight into how an ion channel involved in activation of neurons is gated.
- T and B Cells’ Intricate Molecular Dance
Live-cell imaging in mice reveals the molecular details of B cell selection in germinal centers.
- Push Me, Pull You, That’s the Way to Move
Human fibroblast migration in a physiological extracellular matrix relies on a polarized intracellular pressure gradient.
