Phosphorylation of the TATA-binding protein activates the spliced leader silencing pathway in Trypanosoma brucei

Ronen Hope; Efrat Ben-Mayor; Nehemya Friedman; Konstantin Voloshin; Dipul Biswas; Devorah Matas; Yaron Drori; Arthur Günzl; Shulamit Michaeli

doi:10.1126/scisignal.2005234

Research ArticleParasitology

Phosphorylation of the TATA-binding protein activates the spliced leader silencing pathway in Trypanosoma brucei

Ronen Hope¹,
Efrat Ben-Mayor¹,
Nehemya Friedman¹,
Konstantin Voloshin¹,
Dipul Biswas¹,
Devorah Matas¹,
Yaron Drori¹,
Arthur Günzl², and
Shulamit Michaeli¹,*

¹The Mina and Everard Goodman Faculty of Life Sciences, and Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan 52900, Israel.
²Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.

↵*Corresponding author. E-mail: shulamit.michaeli{at}biu.ac.il

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Science Signaling 02 Sep 2014:
Vol. 7, Issue 341, pp. ra85
DOI: 10.1126/scisignal.2005234

Ronen Hope

1The Mina and Everard Goodman Faculty of Life Sciences, and Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan 52900, Israel.

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Efrat Ben-Mayor

1The Mina and Everard Goodman Faculty of Life Sciences, and Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan 52900, Israel.

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Nehemya Friedman

1The Mina and Everard Goodman Faculty of Life Sciences, and Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan 52900, Israel.

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Konstantin Voloshin

1The Mina and Everard Goodman Faculty of Life Sciences, and Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan 52900, Israel.

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Dipul Biswas

1The Mina and Everard Goodman Faculty of Life Sciences, and Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan 52900, Israel.

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Devorah Matas

1The Mina and Everard Goodman Faculty of Life Sciences, and Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan 52900, Israel.

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Yaron Drori

1The Mina and Everard Goodman Faculty of Life Sciences, and Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan 52900, Israel.

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Arthur Günzl

2Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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Shulamit Michaeli

1The Mina and Everard Goodman Faculty of Life Sciences, and Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat-Gan 52900, Israel.

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For correspondence: shulamit.michaeli@biu.ac.il

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Phosphorylation of the TATA-binding protein activates the spliced leader silencing pathway in Trypanosoma brucei

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