Contents
Vol 7, Issue 342
Contents
Research Articles
- Site- and kinase-specific phosphorylation-mediated activation of SLAC1, a guard cell anion channel stimulated by abscisic acid
Kinases from three different families can activate an anion channel that helps plants tolerate drought stress.
- The coordination of S-sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfide
S-Sulfhydration increases the activity of endothelial nitric oxide synthase, an enzyme important in vasodilation.
Review
- Sirtuins and the circadian clock: Bridging chromatin and metabolism
The sirtuin family of protein deactylases contributes to the regulation of circadian functions.
Editors' Choice
- Autophagy Goes Social
Hyperactivation of mTORC1 and associated inhibition of autophagy reduces pruning of dendritic spines in mice and humans with autism spectral disorders.
- Sox2 Holds the Key to Lung Cancer Susceptibility
Susceptibility to oncogenic transformation by K-RAS depends on Sox2-mediated inhibition of Notch signaling.
- Promoting Ciliogenesis with a Prostaglandin
Export of PGE2 by the transporter ABCC4 promotes cilia formation.
- ZEB1 Teams Up with the DNA Damage Response
A protein that mediates epithelial-to-mesenchymal transition enhances DNA repair to prevent radiotherapy-induced death in cancer cells.
- An Irresistible Combination
A large-scale RNA interference screen reveals a new mechanism of imatinib resistance in chronic myeloid leukemia that can be therapeutically targeted.
- Bringing in the Agent of Your Own Destruction
A serum protein that tags along when pathogens enter cells triggers an immune reaction to them.
- Effective to the Bone
Dovitinib is therapeutically active in a subset of patients with prostate cancer bone metastases, partly due to blockade of FGFR-mediated stromal-epithelial interactions in the bone microenvironment.
- Sounding the Alarm for RAGE
Traumatic brain injury induces acute lung injury that negatively impacts the physiology of the donor lung before and after lung transplantation.