Contents

Contents

• Research Articles

  • Site- and kinase-specific phosphorylation-mediated activation of SLAC1, a guard cell anion channel stimulated by abscisic acid

    By Tobias Maierhofer, Marion Diekmann, Jan Niklas Offenborn, Christof Lind, Hubert Bauer, Kenji Hashimoto, Khaled A. S. Al-Rasheid, Sheng Luan, Jörg Kudla, Dietmar Geiger, Rainer Hedrich

    Science Signaling09 Sep 2014 : ra86 Full AccessRestricted Access

    Kinases from three different families can activate an anion channel that helps plants tolerate drought stress.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • The coordination of S-sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfide

    By Zaid Altaany, YoungJun Ju, Guangdong Yang, Rui Wang

    Science Signaling09 Sep 2014 : ra87 Full AccessRestricted Access

    S-Sulfhydration increases the activity of endothelial nitric oxide synthase, an enzyme important in vasodilation.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Review

  • Sirtuins and the circadian clock: Bridging chromatin and metabolism

    By Selma Masri, Paolo Sassone-Corsi

    Science Signaling09 Sep 2014 : re6 Full AccessRestricted Access

    The sirtuin family of protein deactylases contributes to the regulation of circadian functions.

    • Abstract
    • Full Text
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• Editors' Choice

  • Autophagy Goes Social

    By Jason D. Berndt

    Science Signaling09 Sep 2014 : ec242 Full AccessRestricted Access

    Hyperactivation of mTORC1 and associated inhibition of autophagy reduces pruning of dendritic spines in mice and humans with autism spectral disorders.

    • Abstract

  • Sox2 Holds the Key to Lung Cancer Susceptibility

    By Nancy R. Gough

    Science Signaling09 Sep 2014 : ec243 Full AccessRestricted Access

    Susceptibility to oncogenic transformation by K-RAS depends on Sox2-mediated inhibition of Notch signaling.

    • Abstract

  • Promoting Ciliogenesis with a Prostaglandin

    By Wei Wong

    Science Signaling09 Sep 2014 : ec244 Full AccessRestricted Access

    Export of PGE₂ by the transporter ABCC4 promotes cilia formation.

    • Abstract

  • ZEB1 Teams Up with the DNA Damage Response

    By Leslie K. Ferrarelli

    Science Signaling09 Sep 2014 : ec245 Full AccessRestricted Access

    A protein that mediates epithelial-to-mesenchymal transition enhances DNA repair to prevent radiotherapy-induced death in cancer cells.

    • Abstract

  • An Irresistible Combination

    By Yevgeniya Nusinovich

    Science Signaling09 Sep 2014 : ec246 Full AccessRestricted Access

    A large-scale RNA interference screen reveals a new mechanism of imatinib resistance in chronic myeloid leukemia that can be therapeutically targeted.

    • Abstract

  • Bringing in the Agent of Your Own Destruction

    By Stella M. Hurtley

    Science Signaling09 Sep 2014 : ec247 Full AccessRestricted Access

    A serum protein that tags along when pathogens enter cells triggers an immune reaction to them.

    • Abstract

  • Effective to the Bone

    By Yevgeniya Nusinovich

    Science Signaling09 Sep 2014 : ec248 Full AccessRestricted Access

    Dovitinib is therapeutically active in a subset of patients with prostate cancer bone metastases, partly due to blockade of FGFR-mediated stromal-epithelial interactions in the bone microenvironment.

    • Abstract

  • Sounding the Alarm for RAGE

    By Orla Smith

    Science Signaling09 Sep 2014 : ec249 Full AccessRestricted Access

    Traumatic brain injury induces acute lung injury that negatively impacts the physiology of the donor lung before and after lung transplantation.

    • Abstract