Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis

Kenji Daigo; Makoto Nakakido; Riuko Ohashi; Rie Fukuda; Koichi Matsubara; Takashi Minami; Naotaka Yamaguchi; Kenji Inoue; Shuying Jiang; Makoto Naito; Kouhei Tsumoto; Takao Hamakubo

doi:10.1126/scisignal.2005522

Research ArticlesSEPSIS

Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis

Kenji Daigo¹,*,
Makoto Nakakido²,†,
Riuko Ohashi³,⁴,
Rie Fukuda¹,
Koichi Matsubara³,
Takashi Minami⁵,
Naotaka Yamaguchi⁶,
Kenji Inoue⁷,
Shuying Jiang³,⁸,⁹,
Makoto Naito³,
Kouhei Tsumoto², and
Takao Hamakubo¹,‡

¹Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan.
²Laboratory of Medical Proteomics, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
³Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
⁴Department of Pathology, Niigata University Medical and Dental Hospital, Niigata 951-8520, Japan.
⁵Laboratory for Vascular Biology, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan.
⁶Department of Emergency and Critical Care Medicine, Juntendo University Nerima Hospital, Tokyo 177-8521, Japan.
⁷Department of Cardiology, Juntendo University Nerima Hospital, Tokyo 177-8521, Japan.
⁸Niigata College of Medical Technology, Niigata 950-2076, Japan.
⁹Perseus Proteomics Inc., Tokyo 153-0041, Japan.

↵‡Corresponding author. E-mail: hamakubo{at}qbm.rcast.u-tokyo.ac.jp

↵* Present address: Humanitas Clinical and Research Center, Rozzano, Milan 20089, Italy.
↵† Present address: Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

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Science Signaling 16 Sep 2014:
Vol. 7, Issue 343, pp. ra88
DOI: 10.1126/scisignal.2005522

Kenji Daigo

1Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan.

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Makoto Nakakido

2Laboratory of Medical Proteomics, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

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Riuko Ohashi

3Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.

4Department of Pathology, Niigata University Medical and Dental Hospital, Niigata 951-8520, Japan.

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Rie Fukuda

1Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan.

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Koichi Matsubara

3Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.

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Takashi Minami

5Laboratory for Vascular Biology, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan.

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Naotaka Yamaguchi

6Department of Emergency and Critical Care Medicine, Juntendo University Nerima Hospital, Tokyo 177-8521, Japan.

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Kenji Inoue

7Department of Cardiology, Juntendo University Nerima Hospital, Tokyo 177-8521, Japan.

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Shuying Jiang

3Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.

8Niigata College of Medical Technology, Niigata 950-2076, Japan.

9Perseus Proteomics Inc., Tokyo 153-0041, Japan.

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Makoto Naito

3Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.

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Kouhei Tsumoto

2Laboratory of Medical Proteomics, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

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Takao Hamakubo

1Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan.

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For correspondence: hamakubo@qbm.rcast.u-tokyo.ac.jp

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Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis

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