Research ArticlesSEPSIS
Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis
- Kenji Daigo1,*,
- Makoto Nakakido2,†,
- Riuko Ohashi3,4,
- Rie Fukuda1,
- Koichi Matsubara3,
- Takashi Minami5,
- Naotaka Yamaguchi6,
- Kenji Inoue7,
- Shuying Jiang3,8,9,
- Makoto Naito3,
- Kouhei Tsumoto2, and
- Takao Hamakubo1,‡
- 1Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan.
- 2Laboratory of Medical Proteomics, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
- 3Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
- 4Department of Pathology, Niigata University Medical and Dental Hospital, Niigata 951-8520, Japan.
- 5Laboratory for Vascular Biology, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan.
- 6Department of Emergency and Critical Care Medicine, Juntendo University Nerima Hospital, Tokyo 177-8521, Japan.
- 7Department of Cardiology, Juntendo University Nerima Hospital, Tokyo 177-8521, Japan.
- 8Niigata College of Medical Technology, Niigata 950-2076, Japan.
- 9Perseus Proteomics Inc., Tokyo 153-0041, Japan.
- ↵‡Corresponding author. E-mail: hamakubo{at}qbm.rcast.u-tokyo.ac.jp
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↵* Present address: Humanitas Clinical and Research Center, Rozzano, Milan 20089, Italy.
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↵† Present address: Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
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Science Signaling 16 Sep 2014:
Vol. 7, Issue 343, pp. ra88
DOI: 10.1126/scisignal.2005522
