Contents

Contents

• Research Article

  • Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium

    By Pei-Yu Chen, Lingfeng Qin, George Tellides, Michael Simons

    Science Signaling23 Sep 2014 : ra90 Full AccessRestricted Access

    Endothelial-to-mesenchymal transition is suppressed by FGFR1 signaling.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Review

  • Signaling mechanisms of the epithelial-mesenchymal transition

    By David M. Gonzalez, Damian Medici

    Science Signaling23 Sep 2014 : re8 Full AccessRestricted Access

    Signals from the microenvironment trigger epithelial-mesenchymal transition in development and disease through multiple, crosstalking pathways.

    • Abstract
    • Full Text
    • PDF

• Letters

  • Comment on “Controlling long-term signaling: Receptor dynamics determine attenuation and refractory behavior of the TGF-β pathway”—Smad2/3 activity does not predict the dynamics of transcription

    By Aryeh Warmflash, Qixiang Zhang, Ali H. Brivanlou, Eric D. Siggia

    Science Signaling23 Sep 2014 : lc1 Full AccessRestricted Access

    This pair of Letters discusses the differences between analyzing the dynamics of TGF-β signaling by measuring Smad phosphorylation or by assaying target gene expression.

    • Abstract
    • Full Text
    • PDF

  • Response to comment on “Controlling long-term signaling: Receptor dynamics determine attenuation and refractory behavior of the TGF-β pathway”—Smad2/3 activity does not predict the dynamics of transcription

    By Pedro Vizán, Daniel S. J. Miller, Bernhard Schmierer, Caroline S. Hill

    Science Signaling23 Sep 2014 : lc2 Full AccessRestricted Access

    This pair of Letters discusses the differences between analyzing the dynamics of TGF-β signaling by measuring Smad phosphorylation or by assaying target gene expression.

    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 23 September 2014

    By Michael Simons, Annalisa M. VanHook

    Science Signaling23 Sep 2014 : pc26 Full AccessRestricted Access

    Signaling through the receptor FGFR1 prevents endothelial-to-mesenchymal transition by inhibiting TGF-β signaling.

    • Abstract
    • Full Text

• Editors' Choice

  • Polarized VEGF Signaling Outputs

    By Annalisa M. VanHook

    Science Signaling23 Sep 2014 : ec257 Full AccessRestricted Access

    VEGF-A induces different responses in neural microvessel endothelia depending on whether it comes from the blood or the parenchyma.

    • Abstract

  • Treating Diabetes with FGF1

    By Nancy R. Gough

    Science Signaling23 Sep 2014 : ec258 Full AccessRestricted Access

    Studies in mice indicate that fibroblast growth factor 1 can be used as a drug to treat type 2 diabetes.

    • Abstract

  • A Pathway That Controls Our Mood

    By Peter R. Stern

    Science Signaling23 Sep 2014 : ec259 Full AccessRestricted Access

    The relative level of excitation and inhibition controls activity of a brain region that is linked to depression.

    • Abstract

  • Targeting the “Undruggable” MYCN

    By Leslie K. Ferrarelli

    Science Signaling23 Sep 2014 : ec260 Full AccessRestricted Access

    A drug that alters the conformation of the kinase Aurora A prevents its stabilizing interaction with the oncogenic transcription factor MYCN.

    • Abstract

  • Shorter Filaments Yield a Better Antiviral Response

    By Nancy R. Gough

    Science Signaling23 Sep 2014 : ec261 Full AccessRestricted Access

    The pattern-recognition receptor (PRR) LGP2 optimizes the size of the filaments formed between the PRR MDA5 and viral RNA to maximize the antiviral response.

    • Abstract

  • Human Stem Cell Expansion

    By Beverly A. Purnell

    Science Signaling23 Sep 2014 : ec262 Full AccessRestricted Access

    The self-renewal of human hematopoietic stem cells in vitro is enhanced by the pyrimidoindole derivative UM171.

    • Abstract

  • Establishing Memory of Gene Repression

    By Beverly A. Purnell

    Science Signaling23 Sep 2014 : ec263 Full AccessRestricted Access

    Repression is perpetuated across generations and cell divisions via methylated histones and methylating enzymes.

    • Abstract