Contents
Vol 7, Issue 344
Contents
Research Article
- Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium
Endothelial-to-mesenchymal transition is suppressed by FGFR1 signaling.
Review
- Signaling mechanisms of the epithelial-mesenchymal transition
Signals from the microenvironment trigger epithelial-mesenchymal transition in development and disease through multiple, crosstalking pathways.
Letters
- Comment on “Controlling long-term signaling: Receptor dynamics determine attenuation and refractory behavior of the TGF-β pathway”—Smad2/3 activity does not predict the dynamics of transcription
This pair of Letters discusses the differences between analyzing the dynamics of TGF-β signaling by measuring Smad phosphorylation or by assaying target gene expression.
- Response to comment on “Controlling long-term signaling: Receptor dynamics determine attenuation and refractory behavior of the TGF-β pathway”—Smad2/3 activity does not predict the dynamics of transcription
This pair of Letters discusses the differences between analyzing the dynamics of TGF-β signaling by measuring Smad phosphorylation or by assaying target gene expression.
Podcast
- Science Signaling Podcast: 23 September 2014
Signaling through the receptor FGFR1 prevents endothelial-to-mesenchymal transition by inhibiting TGF-β signaling.
Editors' Choice
- Polarized VEGF Signaling Outputs
VEGF-A induces different responses in neural microvessel endothelia depending on whether it comes from the blood or the parenchyma.
- Treating Diabetes with FGF1
Studies in mice indicate that fibroblast growth factor 1 can be used as a drug to treat type 2 diabetes.
- A Pathway That Controls Our Mood
The relative level of excitation and inhibition controls activity of a brain region that is linked to depression.
- Targeting the “Undruggable” MYCN
A drug that alters the conformation of the kinase Aurora A prevents its stabilizing interaction with the oncogenic transcription factor MYCN.
- Shorter Filaments Yield a Better Antiviral Response
The pattern-recognition receptor (PRR) LGP2 optimizes the size of the filaments formed between the PRR MDA5 and viral RNA to maximize the antiviral response.
- Human Stem Cell Expansion
The self-renewal of human hematopoietic stem cells in vitro is enhanced by the pyrimidoindole derivative UM171.
- Establishing Memory of Gene Repression
Repression is perpetuated across generations and cell divisions via methylated histones and methylating enzymes.