Research ArticleVASCULAR BIOLOGY

Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium

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Science Signaling  23 Sep 2014:
Vol. 7, Issue 344, pp. ra90
DOI: 10.1126/scisignal.2005504

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Strategies to Prevent Vascular Scarring

The endothelium that lines blood vessels can undergo a change called endothelial-to-mesenchymal transition (EndMT). EndMT can cause vessel “scarring,” which limits the success of surgical procedures in which blood vessels are grafted onto each other, such as during heart transplantation or coronary bypass surgery. Chen et al. found that the fibroblast growth factor receptor 1 (FGFR1) signaling pathway in endothelial cells prevented EndMT. The researchers performed blood vessel grafting in mice lacking FGFR1 in endothelial cells and found that the vessels showed increased EndMT. Arteries from patients who had rejected heart transplants had less FGFR1 than those from normal individuals. Thus, enhancing FGFR1 activity could improve the outcome of patients with heart disease undergoing surgical procedures.

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