Contents
Vol 7, Issue 345
Contents
Editorial Guide
- Focus Issue: TGF-β and the Mesenchymal Transition in Physiology and Disease
Understanding the complex regulation and context dependence of TGF-β signaling may lead to new therapies for cancer and fibrosis.
Research Articles
- TGF-β–induced epithelial-to-mesenchymal transition proceeds through stepwise activation of multiple feedback loops
Experimental and computational analyses identify multiple cell populations during the epithelial-to-mesenchymal transition.
- Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt–β-catenin–mediated intestinal tumor growth and regeneration
Partial suppression of the inflammatory gp130-Jak-Stat pathway inhibits intestinal tumor growth.
- Association of the EF-hand and PH domains of the guanine nucleotide exchange factor SLAT with IP3 receptor 1 promotes Ca2+ signaling in T cells
Targeting a T cell receptor–dependent protein-protein interaction at the endoplasmic reticulum inhibits T cell activation.
Review
- Emerging from the shade of p53 mutants: N-terminally truncated variants of the p53 family in EMT signaling and cancer progression
Truncated variants of the p53 family alter the tumor microenvironment to promote tumor vascularization, growth, and metastasis.
Podcast
- Science Signaling Podcast: 30 September 2014
The guanine nucleotide exchange factor SLAT promotes T cell activation by binding to IP3 receptor 1 at the endoplasmic reticulum.
Editors' Choice
- Therapeutic Hope for Metastatic Breast Cancer
Inhibiting the kinase p38α may suppress the growth of new metastatic lesions and reduce the growth of established metastatic lesions in breast cancer patients.
- Daily Dance of Synaptic Partners
The number of synapses and the identities of synaptic partners change over the course of a day in circadian pacemaker neurons.
- Mitochondria Are Getting Fat
A fragment of the cytoplasmic tail of the cadherin Fat localizes to the mitochondria and participates in oxidative phosphorylation.
- Autophagy Limits Innate Immune Signaling
Autophagy not only provides a source of nutrients but also limits toxic innate immune signaling.
- Personalized Heart Healing
The decrease of function in the ALDH2*2 genotype disrupts a cardioprotective oxidative stress regulatory circuit.
- Beware of T Cells That Don't Know How to Stop
A mutation in a single copy of the CTLA4 gene in people is associated with immune dysfunction.
- No Bones About It
Heterotopic ossification induced by injuries and burns is mediated by signaling through the SMAD pathway and can be targeted with topical apyrase.
- A Complex Network Makes Simple Pores
The molecular pathways that regulate an essential adult stem cell lineage in plant stomata are dissected.
- Differentiation Rates Regulate Pool Sizes
Embryonic chick and mouse reveal how neural tube differentiation takes on new strategies as development progresses.
- Animal Behavior Follows Rewards
Dopamine promotes spine structural plasticity during a narrow time window in mouse neuron distal dendrites.
Erratum
- Erratum for the Research Article: “Computational Modeling of ERBB2-Amplified Breast Cancer Identifies Combined ErbB2/3 Blockade as Superior to the Combination of MEK and AKT Inhibitors” by D. C. Kirouac, J. Y. Du, J. Lahdenranta, R. Overland, D. Yarar, V. Paragas, E. Pace, C. F. McDonagh, U. B. Nielsen, and M. D. Onsum
The authors correct errors in the equations presented in the Materials and Methods.
