Editors' ChoiceMEDICINE

No Bones About It

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Science Signaling  30 Sep 2014:
Vol. 7, Issue 345, pp. ec270
DOI: 10.1126/scisignal.2005958

Patients with heterotopic ossification, a condition in which small amounts of bone that form in abnormal locations throughout the body, experience pain and have complications in the recovery from burns, trauma, and surgery. Peterson et al. developed a mouse model of heterotopic ossification, investigated the mechanism of this disorder, and used this animal model to demonstrate a potential therapeutic intervention: topical application of apyrase. Although apyrase was only applied to the injury site, it decreased the abnormal formation of bone throughout the body. Other therapies, such as celecoxib and a drug called LDN-193189, were effective as well, suggesting the possibility of multiple therapeutic options for preventing heterotopic ossification in injured patients.

J. R. Peterson, S. De La Rosa, O. Eboda, K. E. Cilwa, S. Agarwal, S. R. Buchman, P. S. Cederna, C. Xi, M. D. Morris, D. N. Herndon, W. Xiao, R. G. Tompkins, P. H. Krebsbach, S. C. Wang, B. Levi, Treatment of heterotopic ossification through remote ATP hydrolysis. Sci. Transl. Med. 6, 255ra132 (2014). [PubMed]

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