PerspectiveBook Review

How to Become a Control Freak

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Science Signaling  14 Oct 2014:
Vol. 7, Issue 347, pp. pe25
DOI: 10.1126/scisignal.2005802

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Review and commentary on Signal Transduction: Principles, Pathways, and Processes, edited by Lewis C. Cantley, Tony Hunter, Richard Sever,and Jeremy Thorner. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 2014. 452 pp. ISBN: 978-0-879699-01-7


For those that view cellular signaling as a tangled mass of cooked spaghetti, a guidebook that introduces shared principles, highlights typical behaviors, and provides clear examples of the uses for these critical pathways should be invaluable. This book provides all of that and more. But it also, perhaps inadvertently, highlights overly reductionist concepts of cellular control. Hopefully, this tome will close the book on that mode of thought and stimulate a new generation to think about and understand how cellular regulation is so tightly integrated—because this is the key to more effective treatments for disease.

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