Research ArticleStructural Biology Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain–modulated complex formation Kai-En Chen1, Shu-Yu Lin1, Mei-Ju Wu1, Meng-Ru Ho1, Abirami Santhanam1, Chia-Cheng Chou1,2, Tzu-Ching Meng1,3,*, and Andrew H. -J. Wang1,2,3,4,*1Institute of Biological Chemistry, Academia Sinica, Taipei 11581, Taiwan.2National Core Facility for Protein Structural Analysis, Academia Sinica, Taipei 11581, Taiwan.3Institute of Biochemical Sciences, National Taiwan University, Taipei 10717, Taiwan.4Graduate Institute of Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11047, Taiwan.↵*Corresponding author. E-mail: tcmeng{at}gate.sinica.edu.tw (T.-C.M.); ahjwang{at}gate.sinica.edu.tw (A.H.-J.W.) See allHide authors and affiliations Science Signaling 14 Oct 2014:Vol. 7, Issue 347, pp. ra98DOI: 10.1126/scisignal.2005722 Kai-En Chen 1Institute of Biological Chemistry, Academia Sinica, Taipei 11581, Taiwan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Shu-Yu Lin 1Institute of Biological Chemistry, Academia Sinica, Taipei 11581, Taiwan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Mei-Ju Wu 1Institute of Biological Chemistry, Academia Sinica, Taipei 11581, Taiwan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Meng-Ru Ho 1Institute of Biological Chemistry, Academia Sinica, Taipei 11581, Taiwan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Abirami Santhanam 1Institute of Biological Chemistry, Academia Sinica, Taipei 11581, Taiwan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Chia-Cheng Chou 1Institute of Biological Chemistry, Academia Sinica, Taipei 11581, Taiwan.2National Core Facility for Protein Structural Analysis, Academia Sinica, Taipei 11581, Taiwan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Tzu-Ching Meng 1Institute of Biological Chemistry, Academia Sinica, Taipei 11581, Taiwan.3Institute of Biochemical Sciences, National Taiwan University, Taipei 10717, Taiwan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: tcmeng@gate.sinica.edu.tw ahjwang@gate.sinica.edu.tw Andrew H. -J. Wang 1Institute of Biological Chemistry, Academia Sinica, Taipei 11581, Taiwan.2National Core Facility for Protein Structural Analysis, Academia Sinica, Taipei 11581, Taiwan.3Institute of Biochemical Sciences, National Taiwan University, Taipei 10717, Taiwan.4Graduate Institute of Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11047, Taiwan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: tcmeng@gate.sinica.edu.tw ahjwang@gate.sinica.edu.tw Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 7 no. 347 ra98 DOI: https://doi.org/10.1126/scisignal.2005722 PubMed: 25314968 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received July 21, 2014Accepted September 24, 2014 . Copyright & Usage: Copyright © 2014, American Association for the Advancement of Science Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: October 2014 to January 2021 AbstractFullPdf Oct 20144734209253 Nov 20149408496 Dec 20141642320 Jan 20151101415 Feb 2015741211 Mar 2015931621 Apr 2015702115 May 201564148 Jun 2015112912 Jul 201589912 Aug 2015211110 Sep 2015112108 Oct 201523713 Nov 201540511 Dec 201554723 Jan 201681811 Feb 20165769 Mar 201667412 Apr 20163726 May 201646813 Jun 20167697 Jul 201670910 Aug 20167057 Sep 20165124 Oct 201611347 Nov 201669210 Dec 20166414 Jan 20178245 Feb 20179985 Mar 201782812 Apr 20174207 May 20174856 Jun 20175121 Jul 20174472 Aug 20175158 Sep 20173745 Oct 20172761 Nov 201746311 Dec 20174138 Jan 201838105 Feb 20186485 Mar 20185654 Apr 20184760 May 20184575 Jun 20183496 Jul 20182092 Aug 201828145 Sep 201819145 Oct 20184590 Nov 201848161 Dec 20184094 Jan 20195060 Feb 20193142 Mar 20197045 Apr 20191784 May 201934168 Jun 201919167 Jul 201917101 Aug 201930259 Sep 20193042 Oct 201945104 Nov 201920112 Dec 20194184 Jan 20203571 Feb 20202732 Mar 20203665 Apr 20204573 May 20205697 Jun 202015105 Jul 20202930 Aug 202013116 Sep 20201972 Oct 20203281 Nov 202033112 Dec 202032234 Jan 202151013 View Full Text
Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain–modulated complex formation By Kai-En Chen, Shu-Yu Lin, Mei-Ju Wu, Meng-Ru Ho, Abirami Santhanam, Chia-Cheng Chou, Tzu-Ching Meng, Andrew H. -J. Wang Science Signaling14 Oct 2014 : ra98 Structural analysis of a phosphatase-kinase complex defines a role for the PDZ domain in regulating kinase inactivation. Supplementary Materials
Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain–modulated complex formation By Kai-En Chen, Shu-Yu Lin, Mei-Ju Wu, Meng-Ru Ho, Abirami Santhanam, Chia-Cheng Chou, Tzu-Ching Meng, Andrew H. -J. Wang Science Signaling14 Oct 2014 : ra98 Structural analysis of a phosphatase-kinase complex defines a role for the PDZ domain in regulating kinase inactivation. Supplementary Materials