Contents
Vol 7, Issue 348
Contents
Research Articles
- Protein kinase D2 is a digital amplifier of T cell receptor–stimulated diacylglycerol signaling in naïve CD8+ T cells
The kinase PKD2 matches the immune response to the intensity of T cell receptor stimulation.
- RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis
Mice lacking the GTPase RhoA in cardiomyocytes develop greater pathological hypertrophy but reduced fibrosis with chronic stress to the heart.
- Notch signaling acts before cell division to promote asymmetric cleavage and cell fate of neural precursor cells
Signaling by Notch is involved early in the precursor cell to regulate asymmetric cell division and cleavage.
Perspective
- Notch activity in neural progenitors coordinates cytokinesis and asymmetric differentiation
Notch signaling acts early to promote asymmetric cell division in Drosophila neural precursor cells.
Editors' Choice
- Bacteria May Mess with Your Mind
Two studies reveal that bacteria release metabolites that can influence neuronal activity.
- ROS to the Rescue!
Epidermal wounding triggers the production of mitochondrial reactive oxygen species that promote cytoskeletal responses necessary for healing.
- Hedgehog: From Foe to Friend in the Battle Against Bladder Cancer
Hedgehog signaling promotes bladder cancer formation, but the loss of hedgehog-mediated stroma-tumor crosstalk contributes to disease progression.
- In Search of a Young and Supple Brain
Inhibition of a cell surface, Ig-like receptor in the adult mouse visual cortex increases neural plasticity and facilitates recovery from amblyopia.
- Transporting the Calcium Signal to the Nucleus
CaMKIIγ delivers Ca2+/CaM from voltage-gated calcium channels to the nucleus.
- Insight into a Retinal Degeneration Disease
A bacterial homolog structure gives insights into ion permeation, gating, and mutations that cause retinal degeneration.
- Tregs Muscle In on the Action
Regulatory T cells ameliorate symptoms of muscular dystrophy by suppressing type 1 inflammatory responses in muscle.
- Finding the Targets of T Cells Gone Bad
In a mouse model of rheumatoid arthritis, autoimmune T cells recognize a protein from the ribosome.
- Cytoskeleton Protects from Stress and Aging
A transcription factor may promote longevity by stabilizing the actin cytoskeleton in nematodes.
- Getting to the Root of a Root Problem
Nitrogen-starved rootlets send small peptides to the shoot to initiate compensatory uptake in other rootlets.
