Research ArticleImmunology

Protein kinase D2 is a digital amplifier of T cell receptor–stimulated diacylglycerol signaling in naïve CD8+ T cells

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Science Signaling  21 Oct 2014:
Vol. 7, Issue 348, pp. ra99
DOI: 10.1126/scisignal.2005477

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Matching Cytokine Production to Stimulus Intensity

T cells of the immune system activate the kinase PKD2 when peptide antigen binds and stimulates the T cell receptor (TCR), resulting in the production of proinflammatory cytokines. Navarro et al. found that low concentrations of peptide antigen activated PKD2 in only a few T cells; however, those cells that responded produced the maximal amount of PKD2 activation. In response to increased amounts of peptide antigen, a greater proportion of T cells exhibited maximal PKD2 activation. These data suggest that PKD2 acts as a digital amplifier of TCR signals so that T cells mount an immune response tailored to the strength of the stimulus and that inhibiting PKD2 may prevent inappropriate T cell activation.

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