Contents
Vol 7, Issue 349
Contents
Editorial Guide
- Focus Issue: Signaling in Neuronal Development, Function, and Disease
New research explores the molecular mechanisms that regulate neuronal development, function, and disease.
Research Articles
- The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma
Targeting the kinase ERK5 may disrupt the activation of an oncogenic transcription factor in a subset of neuroblastoma patients.
- Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington’s disease
Mouse models indicate that mutant huntingtin promotes anabolic signaling to contribute to Huntington’s disease.
Perspective
- ALK pERKs Up MYCN in Neuroblastoma
Identification of a crucial mediator between abnormally active ALK and MYCN reveals a potential combination therapy for several tumor types.
Review
- Reciprocal signaling between translational control pathways and synaptic proteins in autism spectrum disorders
Pathways regulating translation and synaptic function may be interconnected in autism spectrum disorder.
Podcast
- Science Signaling Podcast: 28 October 2014
A mutant form of huntingtin associated with early-onset Huntington's disease promotes anabolic signaling that contributes to motor abnormalities and death in mice.
Editors' Choice
- The Healing Power of Sleep
Epidermal growth factor signaling in a single neuron induces a sleeplike state that allows nematodes to recover from cellular stress.
- Unhinging Muscle Injury
Blocking cleavage of LTBP4 (latent TGF-β binding protein 4) and TGF-β release decreases muscle pathology.
- TRPV1 Activates T Cells
A calcium-permeable channel that acts as a pain receptor in neurons contributes to T cell activation and inflammatory immune responses in mice.
- Rosettes Mark the Branch Point
Vascular branching requires structures called podosome rosettes, which form in a α6β1 integrin-dependent manner.
- Signaling from the Surface and the Nucleus
Angiogenic signals from retinal ganglion cells depend on a G protein–coupled receptor that signals at the plasma membrane and the nucleus.
- Sex Determination Driven by Community Cooperation
A biosynthetic pathway split between young and old individual ferns controls hormonal signaling that regulates sex determination.
- Yap Inhibits Axon Migration
Proteins involved in Hippo signaling control differentiation of cells involved in axon guidance in the developing brain.
- Morphin’ Mutant p85α
Some mutations in a PI3K subunit promote cancer cell proliferation through a PI3K-independent pathway.
- From Single Molecules to Embryos in Living Color
A new microscope allows three-dimensional imaging of living systems at very high resolution in real time.
- Flu Mimics Damaged Proteins During Entry
A flu virus mimics misfolded protein aggregates and hijacks associated cellular machinery early during infection.
