Contents
Vol 7, Issue 350
Contents
Research Articles
- PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation
A feedback loop involving PIP4kγ and mTORC1 maintains basal mTORC1 activity under nutrient-deprived conditions.
- Protein folding creates structure-based, noncontiguous consensus phosphorylation motifs recognized by kinases
Kinases can recognize consensus motifs that are noncontiguous in folded proteins.
Review
- MicroRNAs meet calcium: Joint venture in ER proteostasis
Multiple microRNAs converge to regulate calcium homeostasis in the endoplasmic reticulum.
Editors' Choice
- ALS and Parkinson’s Disease Meet at Mitophagy
Mutations in parkin in Parkinson’s disease or optineurin in ALS impair the same pathway of recognition and clearance of dysfunctional mitochondria.
- Getting By with a Little Help from Your Friends
Systemic infection triggers fucosylation of surface proteins on intestinal epithelia, which supports healthy host-commensal interactions to protect the host.
- Reducing DNA Damage with Tyrosyl-tRNA Synthetase
Tyrosyl-tRNA synthetase translocates to the nucleus in response to oxidative stress and enhances expression of genes that protect against DNA damage.
- Overcoming Staph Infections Is Hardwired
Cystine-knot proteins play an evolutionarily conserved dual function in nerve development and immunity to staphylococcal infection.
- Making Dendritic Arbors During Development
Presynaptic granule cell–derived signals drive competitive dendritic morphogenesis of Purkinje cells.