Contents

Contents

• Research Articles

  • PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation

    By Ashley M. Mackey, Deborah A. Sarkes, Ian Bettencourt, John M. Asara, Lucia E. Rameh

    Science Signaling04 Nov 2014 : ra104 Full AccessRestricted Access

    A feedback loop involving PIP4kγ and mTORC1 maintains basal mTORC1 activity under nutrient-deprived conditions.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Protein folding creates structure-based, noncontiguous consensus phosphorylation motifs recognized by kinases

    By Mariana Lemos Duarte, Darlene Aparecida Pena, Felipe Augusto Nunes Ferraz, Denise Aparecida Berti, Tiago José Paschoal Sobreira, Helio Miranda Costa-Junior, Munira Muhammad Abdel Baqui, Marie-Hélène Disatnik, José Xavier-Neto, Paulo Sérgio Lopes de Oliveira, Deborah Schechtman

    Science Signaling04 Nov 2014 : ra105 Full AccessRestricted Access

    Kinases can recognize consensus motifs that are noncontiguous in folded proteins.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Review

  • MicroRNAs meet calcium: Joint venture in ER proteostasis

    By Fabian Finger, Thorsten Hoppe

    Science Signaling04 Nov 2014 : re11 Full AccessRestricted Access

    Multiple microRNAs converge to regulate calcium homeostasis in the endoplasmic reticulum.

    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • ALS and Parkinson’s Disease Meet at Mitophagy

    By Leslie K. Ferrarelli

    Science Signaling04 Nov 2014 : ec309 Full AccessRestricted Access

    Mutations in parkin in Parkinson’s disease or optineurin in ALS impair the same pathway of recognition and clearance of dysfunctional mitochondria.

    • Abstract

  • Getting By with a Little Help from Your Friends

    By Annalisa M. VanHook

    Science Signaling04 Nov 2014 : ec310 Full AccessRestricted Access

    Systemic infection triggers fucosylation of surface proteins on intestinal epithelia, which supports healthy host-commensal interactions to protect the host.

    • Abstract

  • Reducing DNA Damage with Tyrosyl-tRNA Synthetase

    By Nancy R. Gough

    Science Signaling04 Nov 2014 : ec311 Full AccessRestricted Access

    Tyrosyl-tRNA synthetase translocates to the nucleus in response to oxidative stress and enhances expression of genes that protect against DNA damage.

    • Abstract

  • Overcoming Staph Infections Is Hardwired

    By Stella M. Hurtley

    Science Signaling04 Nov 2014 : ec312 Full AccessRestricted Access

    Cystine-knot proteins play an evolutionarily conserved dual function in nerve development and immunity to staphylococcal infection.

    • Abstract

  • Making Dendritic Arbors During Development

    By Pamela J. Hines

    Science Signaling04 Nov 2014 : ec313 Full AccessRestricted Access

    Presynaptic granule cell–derived signals drive competitive dendritic morphogenesis of Purkinje cells.

    • Abstract