Contents
Vol 7, Issue 351
Contents
Research Articles
- Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65
S-nitrosylation of the deacetylase SIRT1 functions as a proinflammatory switch in aging and inflammatory disorders.
- Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR
Combination therapy with EGFR inhibitors may overcome acquired resistance to PI3K pathway inhibitors in some colorectal cancer patients.
- Type I interferon signaling contributes to the bias that Toll-like receptor 4 exhibits for signaling mediated by the adaptor protein TRIF
The selective use by Toll-like receptor 4 of an adaptor protein may aid in the development of safer vaccine adjuvants.
Editors' Choice
- Knowing Where to S-Nitrosylate
The calcium-regulated inflammatory mediators S100A8 and S100A9 are necessary for site-specific S-nitrosylation.
- Neurons Halt Angiogenesis
Neurons sequester and degrade VEGF to prevent abnormal angiogenesis in the developing retina.
- Cyclin, Notch, and ALL
Cyclin C functions as a tumor suppressor in T cell acute lymphoblastic leukemia by inhibiting Notch signaling.
- Trashing Misfolded Membrane Proteins
A branch of the endoplasmic reticulum–associated protein degradation system degrades inner nuclear membrane proteins in yeast.
