11 November 2014
Vol 7, Issue 351

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Online Cover This week features a Research Article that investigates adaptor protein usage by TLR4, a receptor that is targeted by vaccine adjuvants, which boost the immune response to a vaccine. Whereas one adaptor protein leads to damaging inflammation, the other leads to enhanced immune responses. Previous studies suggested that adjuvant structure determined which adaptor protein TLR4 uses; however, Kolb et al. suggest that TLR4 is inherently biased to preferentially use the immunostimulatory adaptor, findings that may help in the development of safer vaccine adjuvants. [Image: skynesher/iStockphoto]