Contents

Contents

• Research Articles

  • Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65

    By Shohei Shinozaki, Kyungho Chang, Michihiro Sakai, Nobuyuki Shimizu, Marina Yamada, Tomokazu Tanaka, Harumasa Nakazawa, Fumito Ichinose, Yoshitsugu Yamada, Akihito Ishigami, Hideki Ito, Yasuyoshi Ouchi, Marlene E. Starr, Hiroshi Saito, Kentaro Shimokado, Jonathan S. Stamler, Masao Kaneki

    Science Signaling11 Nov 2014 : ra106 Full AccessRestricted Access

    S-nitrosylation of the deacetylase SIRT1 functions as a proinflammatory switch in aging and inflammatory disorders.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR

    By Peter J. Belmont, Ping Jiang, Trevor D. McKee, Tao Xie, Jason Isaacson, Nicole E. Baryla, Jatin Roper, Mark J. Sinnamon, Nathan V. Lee, Julie L. C. Kan, Oivin Guicherit, Bradly G. Wouters, Catherine A. O’Brien, David Shields, Peter Olson, Todd VanArsdale, Scott L. Weinrich, Paul Rejto, James G. Christensen, Valeria R. Fantin, Kenneth E. Hung, Eric S. Martin

    Science Signaling11 Nov 2014 : ra107 Full AccessRestricted Access

    Combination therapy with EGFR inhibitors may overcome acquired resistance to PI3K pathway inhibitors in some colorectal cancer patients.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Type I interferon signaling contributes to the bias that Toll-like receptor 4 exhibits for signaling mediated by the adaptor protein TRIF

    By Joseph P. Kolb, Carolyn R. Casella, Shuvasree SenGupta, Paula M. Chilton, Thomas C. Mitchell

    Science Signaling11 Nov 2014 : ra108 Full AccessRestricted Access

    The selective use by Toll-like receptor 4 of an adaptor protein may aid in the development of safer vaccine adjuvants.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Editors' Choice

  • Knowing Where to S-Nitrosylate

    By Nancy R. Gough

    Science Signaling11 Nov 2014 : ec314 Full AccessRestricted Access

    The calcium-regulated inflammatory mediators S100A8 and S100A9 are necessary for site-specific S-nitrosylation.

    • Abstract

  • Neurons Halt Angiogenesis

    By Jason D. Berndt

    Science Signaling11 Nov 2014 : ec315 Full AccessRestricted Access

    Neurons sequester and degrade VEGF to prevent abnormal angiogenesis in the developing retina.

    • Abstract

  • Cyclin, Notch, and ALL

    By Leslie K. Ferrarelli

    Science Signaling11 Nov 2014 : ec316 Full AccessRestricted Access

    Cyclin C functions as a tumor suppressor in T cell acute lymphoblastic leukemia by inhibiting Notch signaling.

    • Abstract

  • Trashing Misfolded Membrane Proteins

    By Stella M. Hurtley

    Science Signaling11 Nov 2014 : ec317 Full AccessRestricted Access

    A branch of the endoplasmic reticulum–associated protein degradation system degrades inner nuclear membrane proteins in yeast.

    • Abstract