Research ResourceMetabolism

Large-scale functional analysis of the roles of phosphorylation in yeast metabolic pathways

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Science Signaling  25 Nov 2014:
Vol. 7, Issue 353, pp. rs6
DOI: 10.1126/scisignal.2005602

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Mapping the Metabolome

There is a complex interplay between factors in the external environment of a cell and the metabolism of the thousands of molecules inside a cell. This interplay is governed in part by protein phosphorylation. Schulz et al. used mass spectrometry to profile relative concentrations of hundreds of metabolites in Saccharomyces cerevisiae yeast with individual deletions of the genes encoding greater that 100 kinases and phosphatases. Mapping these changes onto a network of metabolic pathways and integrating information about changes in protein phosphorylation in the same yeast deletion strains enabled predictions about the functional relationships between kinases or phosphatases and enzymes involved in cellular metabolism.

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