02 December 2014
Vol 7, Issue 354

About The Cover

Cover image expansion

Online Cover This week features a Research Article showing, by biochemical and structural analysis, how cancer-associated mutations in HER3 increase its allosteric activating ability for EGFR (HER1). The image shows the HER3 and EGFR kinase domain heterodimeric complex with the residues in which cancer-associated mutations occur in HER3 highlighted. [Image: C. Bickel, Science Signaling]