23 December 2014
Vol 7, Issue 357

About The Cover

Cover image expansion

Online Cover This week features a pair of Research Articles on the development and application of a signaling pathway–centric screen that uses "barcoded" cDNAs to discover new targets for therapeutic intervention. Martz et al. describe the screening method and the identification of Notch as a key mediator of drug resistance in diverse cancers. Winter et al. describe the application of this method to identify combination therapies for acute myeloid leukemia. [Image: S. Grandy/iStockphoto; C. Bickel/Science Signaling]