Contents
Vol 8, Issue 358
Contents
Editorial Guide
- 2014: Signaling Breakthroughs of the Year
The year’s highlights include molecular and functional insights into innate immunity, host-microbe interactions, and cell death and new techniques to study cell signaling.
Research Articles
- The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling
A kinase that controls cell division also promotes the activity of the transforming growth factor–β pathway.
- Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation
Peroxidized lipid metabolites trigger calcium influx through the channel TRPA1 to dilate cerebral arteries.
Podcast
- Science Signaling Podcast: 6 January 2015
Reactive oxygen species create peroxidized lipids that promote dilation of cerebral arteries by activating the ion channel TRPA1.
Editors' Choice
- Insulin Promotes Serotonin Uptake
Trophoblasts of patients with gestational diabetes exhibit increased serotonin due to impaired processing and trafficking of the serotonin uptake transporter.
- Guiding Axons with Two Slits
Whereas one fragment of Slit signals through Robo, the other triggers PlexinA1 to mediate axon guidance in the developing brain.
- Senescent Cells Promote Tissue Repair
Release of the growth factor PDGF-AA from senescent cells at skin wounds aids in healing.
- Skin Infection Triggers Fat Responses
The subcutaneous fat layer thickens during infection and stimulates adipocytes to secrete a protective peptide.
- Cashing In with ATM
Reducing ATM signaling is neuroprotective in cell and animal models of Huntington’s disease.
- Lysosomes Signal the Nucleus to Control Aging
The metabolism of fats in the lysosome signals the nucleus to control aging.
- mTOR and Human Aging
Elderly volunteers produce an enhanced immune response to an influenza vaccine when mTOR is inhibited.
