Contents

Contents

• Editorial Guide

  • 2014: Signaling Breakthroughs of the Year

    By Jason D. Berndt, Wei Wong

    Science Signaling06 Jan 2015 : eg1 Full AccessRestricted Access

    The year’s highlights include molecular and functional insights into innate immunity, host-microbe interactions, and cell death and new techniques to study cell signaling.

    • Abstract
    • Full Text
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• Research Articles

  • The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling

    By Shyam Nyati, Katrina Schinske-Sebolt, Sethuramasundaram Pitchiaya, Katerina Chekhovskiy, Areeb Chator, Nauman Chaudhry, Joseph Dosch, Marcian E. Van Dort, Sooryanarayana Varambally, Chandan Kumar-Sinha, Mukesh Kumar Nyati, Dipankar Ray, Nils G. Walter, Hongtao Yu, Brian Dale Ross, Alnawaz Rehemtulla

    Science Signaling06 Jan 2015 : ra1 Full AccessRestricted Access

    A kinase that controls cell division also promotes the activity of the transforming growth factor–β pathway.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Localized TRPA1 channel Ca²⁺ signals stimulated by reactive oxygen species promote cerebral artery dilation

    By Michelle N. Sullivan, Albert L. Gonzales, Paulo W. Pires, Allison Bruhl, M. Dennis Leo, Wencheng Li, Agathe Oulidi, Frederick A. Boop, Yumei Feng, Jonathan H. Jaggar, Donald G. Welsh, Scott Earley

    Science Signaling06 Jan 2015 : ra2 Full AccessRestricted Access

    Peroxidized lipid metabolites trigger calcium influx through the channel TRPA1 to dilate cerebral arteries.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Podcast

  • Science Signaling Podcast: 6 January 2015

    By Scott Earley, Annalisa M. VanHook

    Science Signaling06 Jan 2015 : pc1 Full AccessRestricted Access

    Reactive oxygen species create peroxidized lipids that promote dilation of cerebral arteries by activating the ion channel TRPA1.

    • Abstract
    • Full Text

• Editors' Choice

  • Insulin Promotes Serotonin Uptake

    By Nancy R. Gough

    Science Signaling06 Jan 2015 : ec1 Full AccessRestricted Access

    Trophoblasts of patients with gestational diabetes exhibit increased serotonin due to impaired processing and trafficking of the serotonin uptake transporter.

    • Abstract

  • Guiding Axons with Two Slits

    By Leslie K. Ferrarelli

    Science Signaling06 Jan 2015 : ec2 Full AccessRestricted Access

    Whereas one fragment of Slit signals through Robo, the other triggers PlexinA1 to mediate axon guidance in the developing brain.

    • Abstract

  • Senescent Cells Promote Tissue Repair

    By Nancy R. Gough

    Science Signaling06 Jan 2015 : ec3 Full AccessRestricted Access

    Release of the growth factor PDGF-AA from senescent cells at skin wounds aids in healing.

    • Abstract

  • Skin Infection Triggers Fat Responses

    By Caroline Ash

    Science Signaling06 Jan 2015 : ec4 Full AccessRestricted Access

    The subcutaneous fat layer thickens during infection and stimulates adipocytes to secrete a protective peptide.

    • Abstract

  • Cashing In with ATM

    By Orla Smith

    Science Signaling06 Jan 2015 : ec5 Full AccessRestricted Access

    Reducing ATM signaling is neuroprotective in cell and animal models of Huntington’s disease.

    • Abstract

  • Lysosomes Signal the Nucleus to Control Aging

    By L. Bryan Ray

    Science Signaling06 Jan 2015 : ec6 Full AccessRestricted Access

    The metabolism of fats in the lysosome signals the nucleus to control aging.

    • Abstract

  • mTOR and Human Aging

    By Orla Smith

    Science Signaling06 Jan 2015 : ec7 Full AccessRestricted Access

    Elderly volunteers produce an enhanced immune response to an influenza vaccine when mTOR is inhibited.

    • Abstract