Research ArticleVASCULAR BIOLOGY

Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation

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Science Signaling  06 Jan 2015:
Vol. 8, Issue 358, pp. ra2
DOI: 10.1126/scisignal.2005659

Blood Vessel Dilation with Peroxidized Lipids

Cerebral arteries must maintain constant blood flow to the brain even though blood pressure fluctuates constantly. Sullivan et al. characterized a signaling pathway that is specific to the endothelial cells that line cerebral arteries. Reactive oxygen species (ROS) cause lipid peroxidation. In endothelial cells in cerebral arteries, locally produced ROS oxidized lipids, which triggered calcium influx through the ion channel TRPA1. In turn, this calcium influx activated a potassium-permeable channel, resulting in dilation of cerebral arteries.