Contents
Vol 8, Issue 360
Contents
Research Articles
- Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK
Heparin binds and activates the receptor tyrosine kinase ALK, which has no known ligand.
- Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer
Small-molecule inhibitors of the lipid phosphatase synaptojanin 2 may prevent breast cancer metastasis.
- The regulatory subunits of PI3Kγ control distinct neutrophil responses
Migration of neutrophils to sites of infection and their generation of reactive oxygen species depend on different regulatory subunits of PI3Kγ.
Editors' Choice
- Blocking DAMPs but not PAMPs
A peptide inhibitor specifically blocks activation of the receptor TLR4 by damage-associated, but not pathogen-associated, molecular patterns.
- Toxin-induced reproduction
A bacterial-derived toxin stimulates sporulation of a pathogenic fungus in mixed-species biofilms.
- Endocannabinoids in glucocorticoid-induced metabolic syndrome
Peripheral endocannabinoid signaling contributes to the metabolic syndrome associated with chronic glucocorticoid administration.
- RAS signaling unleashed in breast cancer
The GTPases RND1 and RAS cooperate to promote epithelial-to-mesenchymal transition and metastasis.
- Turning viral persistence on and off
The antiviral cytokine interferon-λ cures persistent norovirus infection in mice.
- For vaccines, CD4+ T cells can spell trouble
Severe immunopathology kills virally infected mice that received vaccines targeting only CD4+ T cells.
Erratum
- Erratum for the Editorial Guide: “2014: Signaling Breakthroughs of the Year” by J. D. Berndt and W. Wong
The editors correct an erroneous statement about the findings of a paper cited in an editorial guide.
Focus
- A ligand for ALK
Heparin binds and activates the receptor tyrosine kinase ALK.
