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Research ArticleCell Biology
Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK
- Phillip B. Murray1,
- Irit Lax1,
- Andrey Reshetnyak1,
- Gwenda F. Ligon2,
- Jay S. Lillquist2,
- Edward J. Natoli Jr.2,
- Xiarong Shi1,
- Ewa Folta-Stogniew3,
- Murat Gunel4,5,
- Diego Alvarado2, and
- Joseph Schlessinger1,*
- 1Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
- 2Kolltan Pharmaceuticals, New Haven, CT 06520, USA.
- 3Keck Foundation Biotechnology Resource Laboratory, Yale University, New Haven, CT 06520, USA.
- 4Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA.
- 5Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
- ↵*Corresponding author. E-mail: joseph.schlessinger{at}yale.edu
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Science Signaling 20 Jan 2015:
Vol. 8, Issue 360, pp. ra6
DOI: 10.1126/scisignal.2005916
Vol. 8, Issue 360, pp. ra6
DOI: 10.1126/scisignal.2005916
Phillip B. Murray
1Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
Irit Lax
1Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
Andrey Reshetnyak
1Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
Gwenda F. Ligon
2Kolltan Pharmaceuticals, New Haven, CT 06520, USA.
Jay S. Lillquist
2Kolltan Pharmaceuticals, New Haven, CT 06520, USA.
Edward J. Natoli Jr.
2Kolltan Pharmaceuticals, New Haven, CT 06520, USA.
Xiarong Shi
1Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
Ewa Folta-Stogniew
3Keck Foundation Biotechnology Resource Laboratory, Yale University, New Haven, CT 06520, USA.
Murat Gunel
4Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA.
5Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
Diego Alvarado
2Kolltan Pharmaceuticals, New Haven, CT 06520, USA.
Joseph Schlessinger
1Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
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