Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK

Phillip B. Murray; Irit Lax; Andrey Reshetnyak; Gwenda F. Ligon; Jay S. Lillquist; Edward J. Natoli; Xiarong Shi; Ewa Folta-Stogniew; Murat Gunel; Diego Alvarado; Joseph Schlessinger

doi:10.1126/scisignal.2005916

Research ArticleCell Biology

Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK

Phillip B. Murray¹,
Irit Lax¹,
Andrey Reshetnyak¹,
Gwenda F. Ligon²,
Jay S. Lillquist²,
Edward J. Natoli Jr.²,
Xiarong Shi¹,
Ewa Folta-Stogniew³,
Murat Gunel⁴,⁵,
Diego Alvarado², and
Joseph Schlessinger¹,*

¹Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
²Kolltan Pharmaceuticals, New Haven, CT 06520, USA.
³Keck Foundation Biotechnology Resource Laboratory, Yale University, New Haven, CT 06520, USA.
⁴Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA.
⁵Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.

↵*Corresponding author. E-mail: joseph.schlessinger{at}yale.edu

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Science Signaling 20 Jan 2015:
Vol. 8, Issue 360, pp. ra6
DOI: 10.1126/scisignal.2005916

Phillip B. Murray

1Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.

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Irit Lax

1Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.

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Andrey Reshetnyak

1Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.

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Gwenda F. Ligon

2Kolltan Pharmaceuticals, New Haven, CT 06520, USA.

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Jay S. Lillquist

2Kolltan Pharmaceuticals, New Haven, CT 06520, USA.

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Edward J. Natoli Jr.

2Kolltan Pharmaceuticals, New Haven, CT 06520, USA.

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Xiarong Shi

1Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.

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Ewa Folta-Stogniew

3Keck Foundation Biotechnology Resource Laboratory, Yale University, New Haven, CT 06520, USA.

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Murat Gunel

4Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA.

5Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.

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Diego Alvarado

2Kolltan Pharmaceuticals, New Haven, CT 06520, USA.

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Joseph Schlessinger

1Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.

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For correspondence: joseph.schlessinger@yale.edu

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