Research ArticleImmunology

The regulatory subunits of PI3Kγ control distinct neutrophil responses

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Science Signaling  20 Jan 2015:
Vol. 8, Issue 360, pp. ra8
DOI: 10.1126/scisignal.2005564

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Not All PIP3 Is Equal

Neutrophils are immune cells that migrate to sites of infection and generate reactive oxygen species (ROS) to kill pathogens. Both functions depend on the heterodimeric kinase PI3Kγ, which consists of the catalytic p110γ subunit and either a p101 or p84 regulatory subunit. PI3Kγ generates the phospholipid PIP3, which is required for the activation of downstream effectors. Deladeriere et al. generated p84-deficient mice and found that their neutrophils had defects in GPCR-dependent PIP3 generation, which were similar to those of previously described p101-deficient neutrophils. However, unlike loss of p101, which impairs migration, loss of p84 resulted in reduced ROS generation without affecting neutrophil migration. These results suggest that, although the p84 and p101 subunits similarly promote PIP3 production, they enable PI3Kγ signaling to mediate distinct neutrophil functions.

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