Contents
Vol 8, Issue 361
Contents
Research Articles
- Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer
Mutant KRAS promotes mitosis by stimulating phosphorylation of the adaptor protein FADD.
- Leukotriene B4–mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes
Inhibiting the production of a leukotriene may help type 1 diabetic patients from succumbing to sepsis.
- Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatocytes during sepsis limits inflammation through cGMP signaling
Drugs used to treat erectile dysfunction may be repurposed to inhibit inflammation and treat patients with sepsis.
Editors' Choice
- Venom induces insulin shock
Predatory snails use weaponized insulin to disable vertebrate prey.
- Mutant KRAS triggers an inflammatory attraction
Oncogenic KRAS in the pancreas attracts proinflammatory macrophages by inducing the secretion of a chemokine.
- Fewer lesions, more baby mice
The estrogen-dependent inflammatory and neuroangiogenic activities that drive endometriosis can be suppressed by estrogen receptor ligands in mice.