Contents

Contents

• Research Articles

  • Phosphorylation of FADD by the kinase CK1α promotes KRAS^G12D-induced lung cancer

    By Brittany M. Bowman, Katrina A. Sebolt, Benjamin A. Hoff, Jennifer L. Boes, Danette L. Daniels, Kevin A. Heist, Craig J. Galbán, Rajiv M. Patel, Jianke Zhang, David G. Beer, Brian D. Ross, Alnawaz Rehemtulla, Stefanie Galbán

    Science Signaling27 Jan 2015 : ra9 Full AccessRestricted Access

    Mutant KRAS promotes mitosis by stimulating phosphorylation of the adaptor protein FADD.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Leukotriene B₄–mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes

    By Luciano Ribeiro Filgueiras, Stephanie L. Brandt, Soujuan Wang, Zhuo Wang, David L. Morris, Carmella Evans-Molina, Raghavendra G. Mirmira, Sonia Jancar, C. Henrique Serezani

    Science Signaling27 Jan 2015 : ra10 Full AccessRestricted Access

    Inhibiting the production of a leukotriene may help type 1 diabetic patients from succumbing to sepsis.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatocytes during sepsis limits inflammation through cGMP signaling

    By Meihong Deng, Patricia A. Loughran, Liyong Zhang, Melanie J. Scott, Timothy R. Billiar

    Science Signaling27 Jan 2015 : ra11 Full AccessRestricted Access

    Drugs used to treat erectile dysfunction may be repurposed to inhibit inflammation and treat patients with sepsis.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • Venom induces insulin shock

    By Annalisa M. VanHook

    Science Signaling27 Jan 2015 : ec19 Full AccessRestricted Access

    Predatory snails use weaponized insulin to disable vertebrate prey.

    • Abstract

  • Mutant KRAS triggers an inflammatory attraction

    By Leslie K. Ferrarelli

    Science Signaling27 Jan 2015 : ec20 Full AccessRestricted Access

    Oncogenic KRAS in the pancreas attracts proinflammatory macrophages by inducing the secretion of a chemokine.

    • Abstract

  • Fewer lesions, more baby mice

    By Nancy R. Gough

    Science Signaling27 Jan 2015 : ec21 Full AccessRestricted Access

    The estrogen-dependent inflammatory and neuroangiogenic activities that drive endometriosis can be suppressed by estrogen receptor ligands in mice.

    • Abstract

  • Turned off by chloride

    By Nancy R. Gough

    Science Signaling27 Jan 2015 : ec22 Full AccessRestricted Access

    Na⁺/HCO₃^- transporters are inhibited by intracellular Cl^-.

    • Abstract