Research ArticleInflammation

Leukotriene B4–mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes

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Science Signaling  27 Jan 2015:
Vol. 8, Issue 361, pp. ra10
DOI: 10.1126/scisignal.2005568

Preventing sepsis in type 1 diabetics

Patients with type 1 diabetes have chronic systemic inflammation and are more prone to developing sepsis. Filgueiras et al. found that mice that are a model for type 1 diabetes had higher amounts of leukotriene B4, a proinflammatory lipid, and of 5-lipoxygenase, the enzyme that produces leukotriene B4. Mice with type 1 diabetes that were treated with an inhibitor of 5-lipoxygenase survived sepsis and had decreased markers of inflammation, suggesting that targeting 5-lipoxygenase to prevent the production of leukotriene B4 could decrease the susceptibility of type 1 diabetic patients to sepsis.

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