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Abstract
This Podcast features an interview with Kunxin Luo, senior author of a Research Article that appears in the 10 February 2015 issue of Science Signaling, about how the protein Ski suppresses the progression of breast cancer. Ski is oncogenic in some contexts but acts as a tumor suppressor in other contexts. Rashidian et al. found that, in breast cancer cells, Ski inhibited the activity of TAZ, a transcriptional coactivator that stimulates the expression of growth-promoting genes. Ski interacted with several components of the Hippo pathway to promote the cytosolic sequestration and degradation of TAZ. Furthermore, Ski also inhibited TAZ activity through two Hippo-independent mechanisms. Ski inhibited epithelial-to-mesenchymal transition in cultured breast cancer cells and suppressed metastasis of TAZ-expressing xenografted tumors.
