Research ArticleCancer

Ski regulates Hippo and TAZ signaling to suppress breast cancer progression

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Science Signaling  10 Feb 2015:
Vol. 8, Issue 363, pp. ra14
DOI: 10.1126/scisignal.2005735

Keeping cancers from becoming Hippo sized

Activation of the kinases in the Hippo pathway triggers the phosphorylation, cystolic sequestration, and degradation of the transcriptional coactivator TAZ, preventing the activation of genes that promote cell proliferation and survival. Ski has both pro-oncogenic and anti-oncogenic properties. By investigating the tumor suppressor side of Ski, Rashidian et al. found that Ski inhibited TAZ in breast cancer cells. In the cytosol, Ski enhanced the phosphorylation of TAZ through the Hippo pathway; in the nucleus, Ski recruited a transcriptional co-repressor to TAZ. Thus, Ski may limit breast cancer progression by inhibiting TAZ through Hippo pathway–dependent and Hippo pathway–independent mechanisms.

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