Research ArticlesMechanosensitive Channels

Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides

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Science Signaling  10 Feb 2015:
Vol. 8, Issue 363, pp. ra15
DOI: 10.1126/scisignal.2005667

Channeling analgesia

Ion channels are essential to mediating the sensation of pain and pressure. The chemical in chilis that makes them hot is capsaicin, which activates the calcium-permeable channel TRPV1, and this chemical is also used as a topical analgesic. Borbiro et al. found that capsaicin activation of TRPV1 inhibited the mechanosensitive Piezo channels by depleting specific phosphoinositides in the plasma membrane. These results may explain some of the analgesic effects of this chemical.

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