Research ArticleCancer

The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking

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Sci. Signal.  17 Feb 2015:
Vol. 8, Issue 364, pp. ra18
DOI: 10.1126/scisignal.2005547

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Pez dispenses with metastasis

Tumor cells have an increased amount of growth-promoting receptors on their surfaces, and they secrete factors that promote metastasis. Belle et al. found that the protein tyrosine phosphatase PTPN14 (also called Pez) suppressed the movement of prometastatic proteins toward the cell surface by binding and dephosphorylating the kinase PRKCD or the protein RIN1. Mice bearing breast cancer xenografts that lacked PTPN14 had larger tumors and a greater number of metastases. Breast cancers with decreased abundance of PTPN14 or increased abundance of RIN1 and PRKCD were more advanced. The findings explain how PTPN14 functions as a tumor suppressor.