Research ArticleCalcium signaling

Plasma membrane Ca2+-ATPases can shape the pattern of Ca2+ transients induced by store-operated Ca2+ entry

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Science Signaling  17 Feb 2015:
Vol. 8, Issue 364, pp. ra19
DOI: 10.1126/scisignal.2005672

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Shaping the calcium signal

Cells use spatially and locally controlled calcium signals to regulate specific responses and have multiple mechanisms for regulating cytosolic calcium and for removing cytosolic calcium after stimuli that trigger its increase. Pászty et al. investigated how the Ca2+-ATPases that pump calcium out of the cell (PMCAs) contribute to the shape of calcium signals under conditions in which the internal calcium stores have been depleted and cannot contribute to clearing of the calcium from the cytosol. The pattern of calcium signals (oscillating, sustained elevation, or rapid return to baseline) produced in multiple cultured cell lines depended on the abundance of the specific PMCA isoforms, which have different kinetic and regulatory properties. The authors developed a mathematical model that recapitulated the calcium signaling patterns observed in the cultured cells and used the model to identify which properties of PMCA were critical for producing an oscillating Ca2+ pattern.