Contents
Vol 8, Issue 366
Contents
Editorial Guide
- Focus Issue: Inflammatory mechanisms
Delineating both pro- and anti-inflammatory mechanisms is important to developing effective anti-inflammatory therapies.
Research Articles
- Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU
Calcium signaling stimulates the accumulation of the mitochondrial calcium uniporter to regulate mitochondrial metabolism.
- Control of IL-17 receptor signaling and tissue inflammation by the p38α–MKP-1 signaling axis in a mouse model of multiple sclerosis
A cytokine released by infiltrating lymphocytes activates p38α-dependent signaling in the CNS in a mouse model of multiple sclerosis.
- Viral entry route determines how human plasmacytoid dendritic cells produce type I interferons
A population of dendritic cells can mount an antiviral response when exposed to virally infected cells or when infected themselves with RNA virus.
Editors' Choice
- Calcium regulator hidden in a long “noncoding” RNA
Myoregulin is a micropeptide encoded in a long noncoding RNA and inhibits the sarcoplasmic reticulum Ca2+ pump in skeletal muscle.
- TRAF6 phosphorylation inhibits inflammation
Phosphorylation of the E3 ubiquitin ligase TRAF6 by the kinase MST4 inhibits inflammatory responses in macrophages.
- Epigenetics of addiction
Chronic opiate use represses expression of Brain-derived neurotrophic factor through changes in histone modifications.
- Channeling Ebola virus entry into the cell
Ebola virus requires endosomal two-pore calcium channels to enter host cells.
Focus
- Integrating p38α MAPK immune signals in nonimmune cells
Signaling by p38α in resident cells of the CNS mediates the inflammatory effects of the T cell–derived cytokine interleukin-17 in a mouse model of multiple sclerosis.
