03 March 2015
Vol 8, Issue 366

About The Cover

Cover image expansion

Online Cover This week features a Focus Issue that highlights research investigating the mechanisms that promote and resolve inflammation. A Research Article in this issue demonstrates how T cells that produce the inflammatory cytokine interleukin-17 (IL-17) affect cells of the central nervous system (CNS) in a mouse model of multiple sclerosis (MS). IL-17 causes activation of the kinase p38α in cells of the CNS, which leads to inflammation and demyelination of neurons. Disease severity in mice was reduced by blocking p38α signaling, which may be a therapeutic target for the treatment of MS. The image depicts the infiltration of the CNS by T cells (foreground) and the resulting demyelination of neurons. [Image: Val Altounian, Science Signaling]