Research ArticleCell Biology
Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU
- Santhanam Shanmughapriya1,2,
- Sudarsan Rajan1,2,
- Nicholas E. Hoffman1,2,
- Xueqian Zhang2,
- Shuchi Guo1,2,
- Jill E. Kolesar3,
- Kevin J. Hines1,2,
- Jonathan Ragheb1,2,
- Neelakshi R. Jog4,
- Roberto Caricchio4,
- Yoshihiro Baba5,
- Yandong Zhou6,
- Brett A. Kaufman3,
- Joseph Y. Cheung2,
- Tomohiro Kurosaki5,
- Donald L. Gill6,*, and
- Muniswamy Madesh1,2,*
- 1Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA.
- 2Center for Translational Medicine, Temple University, Philadelphia, PA 19140, USA.
- 3Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.
- 4Department of Medicine, Temple University, Philadelphia, PA 19140, USA.
- 5Laboratory of Lymphocyte Differentiation, World Premiere International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.
- 6Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, PA 17033, USA.
- ↵*Corresponding author. E-mail: madeshm{at}temple.edu (M.M.); dongill{at}psu.edu (D.L.G.)
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Science Signaling 03 Mar 2015:
Vol. 8, Issue 366, pp. ra23
DOI: 10.1126/scisignal.2005673
Vol. 8, Issue 366, pp. ra23
DOI: 10.1126/scisignal.2005673
Santhanam Shanmughapriya
1Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA.
2Center for Translational Medicine, Temple University, Philadelphia, PA 19140, USA.
Sudarsan Rajan
1Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA.
2Center for Translational Medicine, Temple University, Philadelphia, PA 19140, USA.
Nicholas E. Hoffman
1Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA.
2Center for Translational Medicine, Temple University, Philadelphia, PA 19140, USA.
Xueqian Zhang
2Center for Translational Medicine, Temple University, Philadelphia, PA 19140, USA.
Shuchi Guo
1Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA.
2Center for Translational Medicine, Temple University, Philadelphia, PA 19140, USA.
Jill E. Kolesar
3Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.
Kevin J. Hines
1Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA.
2Center for Translational Medicine, Temple University, Philadelphia, PA 19140, USA.
Jonathan Ragheb
1Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA.
2Center for Translational Medicine, Temple University, Philadelphia, PA 19140, USA.
Neelakshi R. Jog
4Department of Medicine, Temple University, Philadelphia, PA 19140, USA.
Roberto Caricchio
4Department of Medicine, Temple University, Philadelphia, PA 19140, USA.
Yoshihiro Baba
5Laboratory of Lymphocyte Differentiation, World Premiere International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.
Yandong Zhou
6Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, PA 17033, USA.
Brett A. Kaufman
3Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.
Joseph Y. Cheung
2Center for Translational Medicine, Temple University, Philadelphia, PA 19140, USA.
Tomohiro Kurosaki
5Laboratory of Lymphocyte Differentiation, World Premiere International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.
Donald L. Gill
6Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, PA 17033, USA.
Muniswamy Madesh
1Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA.
2Center for Translational Medicine, Temple University, Philadelphia, PA 19140, USA.
