Contents

Contents

• Research Articles

  • Conformational activation of visual rhodopsin in native disc membranes

    By Erik Malmerberg, Petra H. M. Bovee-Geurts, Gergely Katona, Xavier Deupi, David Arnlund, Cecilia Wickstrand, Linda C. Johansson, Sebastian Westenhoff, Elena Nazarenko, Gebhard F. X. Schertler, Andreas Menzel, Willem J. de Grip, Richard Neutze

    Science Signaling10 Mar 2015 : ra26 Full AccessRestricted Access

    Structural analysis with TR-WAXS reveals a light-activated conformational change in rhodopsin in native membranes.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma

    By Jordan Wengrod, Ding Wang, Sarah Weiss, Hua Zhong, Iman Osman, Lawrence B. Gardner

    Science Signaling10 Mar 2015 : ra27 Full AccessRestricted Access

    Melanoma-associated mutations in a phosphatase are associated with increased autophagy, a process that can enhance tumor progression.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Review

  • Plasma membrane–associated platforms: Dynamic scaffolds that organize membrane-associated events

    By Veronica Astro, Ivan de Curtis

    Science Signaling10 Mar 2015 : re1 Full AccessRestricted Access

    A core of four proteins organizes sites of exocytosis, extracellular matrix remodeling, and the leading edge of moving cells.

    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 10 March 2015

    By Richard Neutze, Annalisa M. VanHook

    Science Signaling10 Mar 2015 : pc6 Full AccessRestricted Access

    Structural analysis of rhodopsin in native membranes shows real-time conformational changes induced by light.

    • Abstract
    • Full Text

• Editors' Choice

  • From signaling knowledge to personalized therapy

    By Nancy R. Gough

    Science Signaling10 Mar 2015 : ec52 Full AccessRestricted Access

    Understanding the regulation of apoptosis enables prediction of the most effective combination therapies.

    • Abstract

  • Toll receptors wire the olfactory circuit

    By Leslie K. Ferrarelli

    Science Signaling10 Mar 2015 : ec53 Full AccessRestricted Access

    Toll-family receptors Toll-6 and Toll-7 instruct neuron wiring specificity in the olfactory circuit in flies.

    • Abstract

  • How insects survive desiccation and cold

    By Nancy R. Gough

    Science Signaling10 Mar 2015 : ec54 Full AccessRestricted Access

    Peptides designed on the basis of capa, which controls insect renal tubule function, may provide new strategies for insect pest control.

    • Abstract

  • Paving the way for intratumoral T cells

    By Yevgeniya Nusinovich

    Science Signaling10 Mar 2015 : ec55 Full AccessRestricted Access

    Respiratory hyperoxia stimulates lung tumor regression by promoting T cell infiltration into the tumors and decreasing immunosuppression.

    • Abstract

  • Taking antidepressants to heart

    By Angela Colmone

    Science Signaling10 Mar 2015 : ec56 Full AccessRestricted Access

    GRK2 inhibition with paroxetine improves cardiac function independent of its central nervous system effects.

    • Abstract

  • Molecular “go” signals reveal their secrets

    By Kristen L. Mueller

    Science Signaling10 Mar 2015 : ec57 Full AccessRestricted Access

    A pair of crystal structures reveals how viruses mimic both chemokine receptors and chemokines.

    • Abstract

  • How the immune system readies for battle

    By Laura M. Zahn

    Science Signaling10 Mar 2015 : ec58 Full AccessRestricted Access

    Levels of “housekeeping” proteins are maintained directly, but those of immune response proteins depend on more transcription.

    • Abstract