Contents
Vol 8, Issue 367
Contents
Research Articles
- Conformational activation of visual rhodopsin in native disc membranes
Structural analysis with TR-WAXS reveals a light-activated conformational change in rhodopsin in native membranes.
- Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma
Melanoma-associated mutations in a phosphatase are associated with increased autophagy, a process that can enhance tumor progression.
Review
- Plasma membrane–associated platforms: Dynamic scaffolds that organize membrane-associated events
A core of four proteins organizes sites of exocytosis, extracellular matrix remodeling, and the leading edge of moving cells.
Podcast
- Science Signaling Podcast: 10 March 2015
Structural analysis of rhodopsin in native membranes shows real-time conformational changes induced by light.
Editors' Choice
- From signaling knowledge to personalized therapy
Understanding the regulation of apoptosis enables prediction of the most effective combination therapies.
- Toll receptors wire the olfactory circuit
Toll-family receptors Toll-6 and Toll-7 instruct neuron wiring specificity in the olfactory circuit in flies.
- How insects survive desiccation and cold
Peptides designed on the basis of capa, which controls insect renal tubule function, may provide new strategies for insect pest control.
- Paving the way for intratumoral T cells
Respiratory hyperoxia stimulates lung tumor regression by promoting T cell infiltration into the tumors and decreasing immunosuppression.
- Taking antidepressants to heart
GRK2 inhibition with paroxetine improves cardiac function independent of its central nervous system effects.
- Molecular “go” signals reveal their secrets
A pair of crystal structures reveals how viruses mimic both chemokine receptors and chemokines.
- How the immune system readies for battle
Levels of “housekeeping” proteins are maintained directly, but those of immune response proteins depend on more transcription.
