DDR2 (discoidin domain receptor 2) suppresses osteoclastogenesis and is a potential therapeutic target in osteoporosis

Yan Zhang; Jin Su; Shufang Wu; Yue Teng; Zhanhai Yin; Yan Guo; Jing Li; Kun Li; Libo Yao; Xu Li

doi:10.1126/scisignal.2005835

Research ArticlePhysiology

DDR2 (discoidin domain receptor 2) suppresses osteoclastogenesis and is a potential therapeutic target in osteoporosis

Yan Zhang¹,
Jin Su²,
Shufang Wu¹,
Yue Teng¹,
Zhanhai Yin³,
Yan Guo⁴,
Jing Li¹,
Kun Li⁵,
Libo Yao², and
Xu Li¹,*

¹Center for Translational Medicine, the First Affiliated Hospital of Xi’an Jiaotong University College of Medicine, Xi’an, Shaanxi 710061, People’s Republic of China.
²Department of Biochemistry and Molecular Biology, the Fourth Military Medical University, Xi’an, Shaanxi 710032, People’s Republic of China.
³Department of Orthopaedics, the First Affiliated Hospital of Xi’an Jiaotong University College of Medicine, Xi’an, Shaanxi 710061, People’s Republic of China.
⁴Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, People’s Republic of China.
⁵Clinical laboratory, ShanXi Mineral Hospital, Xi’an, Shaanxi 710014, People’s Republic of China.

↵*Corresponding author. E-mail: lixuxjtu{at}163.com

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Science Signaling 24 Mar 2015:
Vol. 8, Issue 369, pp. ra31
DOI: 10.1126/scisignal.2005835

Yan Zhang

1Center for Translational Medicine, the First Affiliated Hospital of Xi’an Jiaotong University College of Medicine, Xi’an, Shaanxi 710061, People’s Republic of China.

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Jin Su

2Department of Biochemistry and Molecular Biology, the Fourth Military Medical University, Xi’an, Shaanxi 710032, People’s Republic of China.

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Shufang Wu

1Center for Translational Medicine, the First Affiliated Hospital of Xi’an Jiaotong University College of Medicine, Xi’an, Shaanxi 710061, People’s Republic of China.

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Yue Teng

1Center for Translational Medicine, the First Affiliated Hospital of Xi’an Jiaotong University College of Medicine, Xi’an, Shaanxi 710061, People’s Republic of China.

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Zhanhai Yin

3Department of Orthopaedics, the First Affiliated Hospital of Xi’an Jiaotong University College of Medicine, Xi’an, Shaanxi 710061, People’s Republic of China.

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Yan Guo

4Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, People’s Republic of China.

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Jing Li

1Center for Translational Medicine, the First Affiliated Hospital of Xi’an Jiaotong University College of Medicine, Xi’an, Shaanxi 710061, People’s Republic of China.

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Kun Li

5Clinical laboratory, ShanXi Mineral Hospital, Xi’an, Shaanxi 710014, People’s Republic of China.

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Libo Yao

2Department of Biochemistry and Molecular Biology, the Fourth Military Medical University, Xi’an, Shaanxi 710032, People’s Republic of China.

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Xu Li

1Center for Translational Medicine, the First Affiliated Hospital of Xi’an Jiaotong University College of Medicine, Xi’an, Shaanxi 710061, People’s Republic of China.

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For correspondence: lixuxjtu@163.com

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