Contents
Vol 8, Issue 370
Contents
Research Articles
- PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion
Cancer-associated mutations in PREX2 enable cells to overcome the tumor-suppressive effects of PTEN.
- Molecular recognition of ketamine by a subset of olfactory G protein–coupled receptors
The anesthetic ketamine activates G protein–coupled receptors involved in smell.
Review
- T lymphocyte regulation by mevalonate metabolism
Metabolites of the mevalonate pathway provide energy, modify critical molecules, and even act as agonists for T cells.
Podcast
- Science Signaling Podcast: 31 March 2015
Mutations in PREX2 overcome tumor suppression by PTEN.
Editors' Choice
- A transcription factor Sox it to bacterial DNA
The transcription factor Sox2 acts as a pattern recognition receptor for cytosolic bacterial DNA in neutrophils.
- Endocannabinoids inhibit Hedgehog signaling
Neuromodulatory lipids called endocannabinoids are natural antagonists of the Hedgehog pathway protein Smoothened.
- Rice that tolerates a chill
Variation in a single amino acid in a transmembrane protein confers cold tolerance to rice.
- Mothers tell daughters to wait for a mate
Exposure to mating pheromone drives cytoplasmic accumulation of a cell cycle inhibitor that determines whether yeast enter mitosis or wait for a mate.
- A lysosomal amino acid sensor for mTORC1
Amino acid transporter SLC38A9 contributes to the amino acid sensitivity of mTORC1 activation.
- New players in Lou Gehrig's disease
Analysis of the expressed genes of nearly 2900 patients with amyotrophic lateral sclerosis and about 6400 controls reveals a disease predisposition–associated gene.
- Exciting nerve cells deep inside the brain
A minimally invasive method allows remote neuronal excitation through the activation of a heat-sensitive receptor by magnetic nanoparticles.
Erratum
- Erratum for the Teaching Resource: “Measurement of Phosphorylated Extracellular Signal–Regulated Kinase 1 and 2 in an Undergraduate Teaching Laboratory with ALPHAscreen Technology” by D. L. Hay
The author corrects errors in specifying volumes and well assignments.
Focus
- Does ketamine target olfactory receptors in the brain?
The finding that the anesthetic ketamine activates distinct olfactory receptors highlights the importance of this class of GPCRs for drug design.
