PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion

Sarah M. Mense; Douglas Barrows; Cindy Hodakoski; Nicole Steinbach; David Schoenfeld; William Su; Benjamin D. Hopkins; Tao Su; Barry Fine; Hanina Hibshoosh; Ramon Parsons

doi:10.1126/scisignal.2005840

Research ArticleCancer

PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion

Sarah M. Mense¹,
Douglas Barrows¹,²,
Cindy Hodakoski¹,
Nicole Steinbach¹,³,
David Schoenfeld¹,³,
William Su¹,
Benjamin D. Hopkins¹,
Tao Su⁴,
Barry Fine⁵,
Hanina Hibshoosh⁴,⁶, and
Ramon Parsons¹,*

¹Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029, USA.
²Department of Pharmacology, Columbia University, New York, NY 10032, USA.
³Integrated Program in Cellular, Molecular, Structural, and Genetic Studies, Columbia University, New York, NY 10032, USA.
⁴Herbert Irving Comprehensive Cancer Center, Columbia University, 1130 St. Nicholas Avenue, New York, NY 10032, USA.
⁵Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA.
⁶Department of Pathology and Cell Biology, Columbia University, 630 West 168th Street, New York, NY 10032, USA.

↵*Corresponding author. E-mail: ramon.parsons{at}mssm.edu

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Science Signaling 31 Mar 2015:
Vol. 8, Issue 370, pp. ra32
DOI: 10.1126/scisignal.2005840

Sarah M. Mense

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029, USA.

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Douglas Barrows

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029, USA.Department of Pharmacology, Columbia University, New York, NY 10032, USA.

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Cindy Hodakoski

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029, USA.

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Nicole Steinbach

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029, USA.Integrated Program in Cellular, Molecular, Structural, and Genetic Studies, Columbia University, New York, NY 10032, USA.

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David Schoenfeld

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William Su

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029, USA.

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Benjamin D. Hopkins

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029, USA.

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Tao Su

Herbert Irving Comprehensive Cancer Center, Columbia University, 1130 St. Nicholas Avenue, New York, NY 10032, USA.

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Barry Fine

Department of Medicine, Columbia University, 630 West 168th Street, New York, NY 10032, USA.

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Hanina Hibshoosh

Herbert Irving Comprehensive Cancer Center, Columbia University, 1130 St. Nicholas Avenue, New York, NY 10032, USA.Department of Pathology and Cell Biology, Columbia University, 630 West 168th Street, New York, NY 10032, USA.

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Ramon Parsons

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY 10029, USA.

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For correspondence: ramon.parsons@mssm.edu

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PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion

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