Contents
Vol 8, Issue 372
Contents
Research Articles
- The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability
Inadequate leucine uptake by maturing red blood cells limits the production of hemoglobin.
- Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization
The kinase CK2 promotes the nuclear function of the deubiquitylase OTUB1 in DNA damage repair.
- Constitutive production of c-di-GMP is associated with mutations in a variant of Pseudomonas aeruginosa with altered membrane composition
Changes in the fatty acid composition of the plasma membrane in an opportunistic pathogen promote biofilm formation.
Podcast
- Science Signaling Podcast: 14 April 2015
Altered fatty acid metabolism enhances the ability of a disease-associated strain of Pseudomonas aeruginosa to form biofilms.
Editors' Choice
- Tailoring talin function
Different configurations of the integrin-talin-vinculin complex may enable talin to sense the different forces in developing tissues.
- Biased memories
Drugs targeting β-arrestin–biased signaling by β-adrenergic receptors may be helpful in memory-related disorders.
- Dual action: Demethylase and ubiquitin ligase
The unexpected E3 ubiquitin ligase activity of a histone demethylase suppresses cancer cell growth.
- Imatinib self-sabotages
The anticancer drug imatinib dampens its own toxicity by inducing a feedback loop that promotes proliferative signaling by fibroblast growth factor.
- Slit halts muscles
Cleavage of Slit generates a membrane-associated N-terminal fragment that halts muscle migration in fly embryos.
- Vitamin D lends a helping hand
Vitamin D promotes tumoricidal activity of macrophages and improves the efficacy of antibody-dependent cellular cytotoxicity.
- Giving protein folding a helping hand
Sephin1 selectively inhibits a protein phosphatase to prevent two protein misfolding diseases in mice.
- Single-molecule assay of ubiquitylation
The basis of an important enzyme-target recognition strategy is revealed at the single-molecule level.
Focus
- Amino acid uptake in erythropoiesis
mTORC1 inhibitors may prevent hemoglobin production, thus potentially explaining why their use can be associated with anemias.
