Research ResourcesCellular Metabolism

Dynamic phosphoproteomics reveals TORC1-dependent regulation of yeast nucleotide and amino acid biosynthesis

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Science Signaling  28 Apr 2015:
Vol. 8, Issue 374, pp. rs4
DOI: 10.1126/scisignal.2005768

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How phosphorylation regulates metabolism

The phosphorylation events triggered directly by or downstream of the protein complex TORC1 enable yeast to adjust their metabolism to respond to changes in nutrient availability or nutritional quality. Oliveira et al. subjected yeast to changes in nutrient quality or to treatment with rapamycin, an inhibitor of TORC1. By temporally correlating changes in metabolite concentrations with phosphorylation events, they identified metabolic enzymes downstream of TORC1 and inferred the effect of phosphorylation on the activity of these enzymes, which included enzymes involved in nucleotide and amino acid metabolism and in carbohydrate storage.

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