Editors' ChoicePosttranslational Modifications

Chromosomes: Let me be your guide

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Sci. Signal.  19 May 2015:
Vol. 8, Issue 377, pp. ec133
DOI: 10.1126/scisignal.aac5783

The correct alignment of chromosomes at the center of the mitotic spindle—the metaphase plate—before cell division is one of the key mechanisms for the maintenance of genomic stability. But is there anything special about the microtubules of the spindle that helps this process? Barisic et al. demonstrate that chromosome alignment at the cell equator is controlled by a specific posttranslational modification of selected microtubules oriented toward the center of the mitotic spindle.

M. Barisic, R. Silva e Sousa, S. K. Tripathy, M. M. Magiera, A. V. Zaytsev, A. L. Pereira, C. Janke, E. L. Grishchuk, H. Maiato, Microtubule detyrosination guides chromosomes during mitosis. Science 348, 799–803 (2015). [Abstract] [Full Text]