26 May 2015
Vol 8, Issue 378

About The Cover

Cover image expansion

Online Cover This week features a Research Article that describes how phosphorylation of a tyrosine in the disordered N-terminal region of ACTN4 functions as a switch exposing a second phosphorylation site, important for regulation of the interaction of ACTN4 with actin. The image shows the predicted conformations of the N-terminal domain containing the two residues that are phosphorylated. [Image: Timothy Travers, Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15260]