Research ArticleCancer

HER2-mTOR signaling–driven breast cancer cells require ER-associated degradation to survive

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Science Signaling  26 May 2015:
Vol. 8, Issue 378, pp. ra52
DOI: 10.1126/scisignal.aaa6922

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Putting more stress on HER2-driven cancer

Cancer cells have increased gene expression and hence protein synthesis, which can induce endoplasmic reticulum (ER) stress. This stress can trigger apoptosis if not alleviated. Using patient and cancer cell line genomic databases, Singh et al. found that HER2-driven breast cancers have increased ER stress–induced signaling. Pharmacologically blocking this pathway caused cell death in cultured HER2-positive cells, including those that were resistant to clinically used HER2 inhibitors.

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