Contents
14 July 2015
Vol 8, Issue 385
Vol 8, Issue 385
Contents
Research Articles
- Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation
Mathematical modeling and imaging analysis reveal the relative contributions of two adaptor proteins to the activation of NF-κB in macrophages.
- The interaction of heparan sulfate proteoglycans with endothelial transglutaminase-2 limits VEGF165-induced angiogenesis
Transglutaminase-2 attenuates blood vessel formation by preventing heparan sulfate from potentiating signaling by a VEGF isoform.
Review
- Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract
Mechanisms of cellular reprogramming fuel cancer development and progression in the gastrointestinal tract.
Editors' Choice
- Periodic dieting promotes health
Adherence to a periodic fast-mimicking diet improves health and promotes longevity.
- Increasing ATP release to increase metastasis
A truncated form of the ATP-releasing channel PANX1 enhances the survival of metastasizing breast cancer cells in the microvasculature.
- Awake, but not hyperactive
Neurons that control wakefulness release both stimulating and inhibiting signals to prevent hyperactivity.
- Limiting innate overreaction
Some people are less susceptible to a hyperactive inflammatory response due to a polymorphism in the E3 ubiquitin ligase HECTD2.
- Immunity pipelines
Factors important for the plant immune response are transferred from chloroplasts to nuclei through stromules.
- Single-cell measurements map immunity
Cytometry meets mass spectrometry to create a functional map of the immune system.
- Structure of a sterol sensor
The structure of a bacterial homolog of insulin-induced trans-membrane sterol receptors elucidates their structure and function.
- Microglia get a gut feeling
Gut microbes promote the maturation and activation of microglia in the brain through the production of short-chain fatty acids.
Focus
- The rise in computational systems biology approaches for understanding NF-κB signaling dynamics
The combination of mathematical modeling with imaging experiments helps to interpret how NF-κB signaling is controlled.
About The Cover
Online Cover This week features a Research Article that shows that transglutaminase-2 prevents heparan sulfate from potentiating signaling by a specific VEGF isoform, thereby attenuating blood vessel formation. The image shows retinal vascularization in a mouse deficient in transglutaminase-2. [Image: Thomas Mathivet/CIRB, CNRS, and INSERM, Paris, France]
