Editors' ChoiceVision

Preventing photoreceptor death after retinal injury

See allHide authors and affiliations

Science Signaling  28 Jul 2015:
Vol. 8, Issue 387, pp. ec207
DOI: 10.1126/scisignal.aad0861

Retinal detachment and subsequent degeneration of the retina can lead to progressive visual decline due to death of photoreceptor cells, the major light-sensing cells within the eye. Early inflammatory mediators, including components of the alternative complement pathway, are increased in the eye of patients with retinal detachment. Using a mouse model of retinal detachment, Sweigard et al. found that blocking the alternative complement pathway through either genetic or pharmacological means protected photoreceptors from cell death.

J. H. Sweigard, H. Matsumoto, K. E. Smith, L. A. Kim, E. I. Paschalis, Y. Okonuki, A. Castillejos, K. Kataoka, E. Hasegawa, R. Yanai, D. Husain, J. D. Lambris, D. Vavvas, J. W. Miller, K. M. Connor, Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury. Sci. Transl. Med. 7, 297ra116 (2015). [Abstract]