Contents
04 August 2015
Vol 8, Issue 388
Vol 8, Issue 388
Contents
Research Articles
- Real-time dynamics of peptide ligand–dependent receptor complex formation in planta
In plants, the flagellin and CLAVATA3 signaling pathways act through induced and preassembled receptor complexes, respectively.
- Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer
Annexin A2–dependent secretion of semaphorin 3D induces metastasis of pancreatic cancer cells.
- The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response
The relative abundance of two related kinases determines whether virus-infected cells die or trigger an antiviral response.
Editors' Choice
- NLRP3: From inflammasome to nucleus
An inflammasome component acts as a transcriptional regulator for the differentiation of a subset of helper T cells.
- Why women feel more pain
Gender-specific differences in the immune response to nerve injury contribute to the increased susceptibility of females to chronic pain.
- GABA, the time keeper
Differences in intracellular chloride concentration of neurons in suprachiasmatic nuclei and neurotransmitter GABA encode seasonal day-night variations.
- Twofold tumor suppression
In addition to promoting the degradation of β-catenin, APC also promotes growth-inhibiting Hippo signaling in the intestine.
- HIF1α slows muscle regeneration
Hypoxia-inducible factor 1α inhibits myogenesis following ischemic injury until an adequate oxygen supply has been restored.
- Systemic infection causes antibiotic-induced hearing loss
The release of LPS from bacteria promotes the uptake and toxicity of antibiotics in the inner ear.
- Less resveratrol is more beneficial
Low-dose resveratrol prevents tumor growth in mice and alters metabolism in human tissues.
- A one-two punch for CML
Increased CD70 induced by tyrosine kinase inhibitors mediates drug resistance in leukemia stem cells.
- S-nitrosylation links obesity and cell stress
Altered S-nitrosylation of a key protein involved in the unfolded protein response interferes with proteostasis in obesity.
- Tumor suppressor p53 linked to immune function
p53 promotes clearance of dead cells and proper immune function.
- How plant parasites evolved to find hosts
Obligate parasitic Orobanchaceae plants germinate after sensing strigolactones exuded from host roots.
- A little toxin can do a lot
An actin-specific toxin employs actin oligomers to subvert cellular functions at very low doses.
Focus
- Plant receptor complexes
Plant peptide ligands can either stabilize preformed receptor complexes or stimulate receptor complex formation.
About The Cover
Online Cover This week features a Research Article that characterizes the relative contributions of the kinases ASK1 and ASK2 to host responses to viruses, such as influenza virus. Whereas both ASK1 and ASK2 mediated apoptosis in virus-infected cells, ASK1 alone mediated the production of the antiviral cytokine type I interferon. Thus, the relative abundance of ASK1 and ASK2 in cells determines the type of response elicited by viral infection. The image shows swine influenza virus particles (yellow) and a host cell. [Image: Dr. Klaus Boller/Science Source]