Research ArticlesMEDICINE Extracellular signal–regulated kinase 5 promotes acute cellular and systemic inflammation Kevin Wilhelmsen1,*, Fengyun Xu1, Katherine Farrar2, Alphonso Tran1, Samira Khakpour2, Shirin Sundar1, Arun Prakash1, Jinhua Wang3, Nathanael S. Gray3, and Judith Hellman1,41Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143, USA.2Graduate Program in Biomedical Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.3Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02215, USA.4Division of Critical Care Medicine and Biomedical Sciences Program, University of California, San Francisco, San Francisco, CA 94143, USA.↵*Corresponding author. E-mail: wilhelmsenk{at}anesthesia.ucsf.edu See allHide authors and affiliations Science Signaling 25 Aug 2015:Vol. 8, Issue 391, pp. ra86DOI: 10.1126/scisignal.aaa3206 Kevin Wilhelmsen 1Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: wilhelmsenk@anesthesia.ucsf.edu Fengyun Xu 1Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Katherine Farrar 2Graduate Program in Biomedical Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Alphonso Tran 1Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Samira Khakpour 2Graduate Program in Biomedical Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Shirin Sundar 1Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Arun Prakash 1Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Jinhua Wang 3Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02215, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Nathanael S. Gray 3Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02215, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Judith Hellman 1Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143, USA.4Division of Critical Care Medicine and Biomedical Sciences Program, University of California, San Francisco, San Francisco, CA 94143, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 8 no. 391 ra86 DOI: https://doi.org/10.1126/scisignal.aaa3206 PubMed: 26307013 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received November 18, 2014Accepted August 7, 2015 . Copyright & Usage: Copyright © 2015, American Association for the Advancement of Science Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: August 2015 to March 2021 AbstractFullPdf Aug 20152430212377 Sep 201532992149 Oct 2015301630 Nov 2015231139 Dec 2015421112 Jan 20161271532 Feb 2016891219 Mar 201685922 Apr 201664918 May 20161001515 Jun 20161261221 Jul 2016811111 Aug 2016101811 Sep 201687614 Oct 201663311 Nov 201687512 Dec 20164915 Jan 201771613 Feb 20179064 Mar 201789712 Apr 20175117 May 20176747 Jun 20177224 Jul 201765410 Aug 20177455 Sep 20174941 Oct 20173242 Nov 20176076 Dec 20173953 Jan 20186537 Feb 20186463 Mar 20185136 Apr 20184161 May 20184756 Jun 20184384 Jul 201829810 Aug 201819112 Sep 201826124 Oct 20183255 Nov 201831122 Dec 20183496 Jan 201920114 Feb 201911378 Mar 20192394 Apr 20194316 May 201993820 Jun 20196244 Jul 20195308 Aug 201924119 Sep 20191195 Oct 2019102813 Nov 20193337 Dec 201973012 Jan 202084011 Feb 202032917 Mar 20203306 Apr 202042924 May 202072211 Jun 20206209 Jul 20203167 Aug 20200145 Sep 202032912 Oct 202071910 Nov 202032510 Dec 202062614 Jan 202173011 Feb 20211205 Mar 2021013 View Full Text
Extracellular signal–regulated kinase 5 promotes acute cellular and systemic inflammation By Kevin Wilhelmsen, Fengyun Xu, Katherine Farrar, Alphonso Tran, Samira Khakpour, Shirin Sundar, Arun Prakash, Jinhua Wang, Nathanael S. Gray, Judith Hellman Science Signaling25 Aug 2015 : ra86 Inhibition of the mitogen-activated protein kinase ERK5 reduces systemic inflammation in mice. Supplementary Materials
Extracellular signal–regulated kinase 5 promotes acute cellular and systemic inflammation By Kevin Wilhelmsen, Fengyun Xu, Katherine Farrar, Alphonso Tran, Samira Khakpour, Shirin Sundar, Arun Prakash, Jinhua Wang, Nathanael S. Gray, Judith Hellman Science Signaling25 Aug 2015 : ra86 Inhibition of the mitogen-activated protein kinase ERK5 reduces systemic inflammation in mice. Supplementary Materials