Extracellular signal–regulated kinase 5 promotes acute cellular and systemic inflammation

Kevin Wilhelmsen; Fengyun Xu; Katherine Farrar; Alphonso Tran; Samira Khakpour; Shirin Sundar; Arun Prakash; Jinhua Wang; Nathanael S. Gray; Judith Hellman

doi:10.1126/scisignal.aaa3206

Research ArticlesMEDICINE

Extracellular signal–regulated kinase 5 promotes acute cellular and systemic inflammation

Kevin Wilhelmsen¹,*,
Fengyun Xu¹,
Katherine Farrar²,
Alphonso Tran¹,
Samira Khakpour²,
Shirin Sundar¹,
Arun Prakash¹,
Jinhua Wang³,
Nathanael S. Gray³, and
Judith Hellman¹,⁴

¹Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143, USA.
²Graduate Program in Biomedical Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
³Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
⁴Division of Critical Care Medicine and Biomedical Sciences Program, University of California, San Francisco, San Francisco, CA 94143, USA.

↵*Corresponding author. E-mail: wilhelmsenk{at}anesthesia.ucsf.edu

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Science Signaling 25 Aug 2015:
Vol. 8, Issue 391, pp. ra86
DOI: 10.1126/scisignal.aaa3206

Kevin Wilhelmsen

1Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143, USA.

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For correspondence: wilhelmsenk@anesthesia.ucsf.edu

Fengyun Xu

1Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143, USA.

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Katherine Farrar

2Graduate Program in Biomedical Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.

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Alphonso Tran

1Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143, USA.

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Samira Khakpour

2Graduate Program in Biomedical Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.

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Shirin Sundar

1Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143, USA.

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Arun Prakash

1Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143, USA.

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Jinhua Wang

3Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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Nathanael S. Gray

3Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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Judith Hellman

1Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143, USA.

4Division of Critical Care Medicine and Biomedical Sciences Program, University of California, San Francisco, San Francisco, CA 94143, USA.

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Extracellular signal–regulated kinase 5 promotes acute cellular and systemic inflammation

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