Axon paths in developing spinal cords

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Science Signaling  01 Sep 2015:
Vol. 8, Issue 392, pp. ec249
DOI: 10.1126/scisignal.aad3209

Sensory neurons entering the spinal cord take different paths as inputs for pain and proprioception diverge. Working with chick and mouse embryos, Guy et al. found that glycerophospholipids produced by radial glial cells guide the axons in the developing spinal cord. A soluble glycerophospholipid released by the cells provided an inhibitory signal to the pain-sensitive axons, keeping them on their own unique pathway.

A. T. Guy, Y. Nagatsuka, N. Ooashi, M. Inoue, A. Nakata, P. Greimel, A. Inoue, T. Nabetani, A. Murayama, K. Ohta, Y. Ito, J. Aoki, Y. Hirabayashi, H. Kamiguchi, Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord. Science 349, 974–977 (2015). [Abstract] [Full Text]

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